Analysis of regeneration mechanisms in auto ransplantation

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Abstract

Search for effective and available methods of stimulation of regenerative processes is a priority task of restorative medicine. Of high interest is a kind of biostimulation that induces activation of metabolic and reparative processes in the whole organism.

Aim. Generalization of the relevant literature data concerning possible mechanisms of biostimulation in transplantation of self tissues of an organism. The results of literature survey showed that there still remain many debatable questions concerning cellular and molecular mechanisms that underlie intermolecular interactions in the stage of regeneration. Stimulating effects of an autotransplant both in the zone of the transplant or in an organism in whole may be caused by mediators and signal molecules released in destruction of the autotransplant tissues and of its perifocal region, and also by bioactive substances produced by immune-competent and stem cells.

Conclusion. Tissue transplants may be used as inductors of production of biologically active substances and activators of immune and/or stromal cells. The latter, in turn, are producers of a number of chemical mediators required for large-scale regeneration. Therefore, a promising method of stimulation of regenerative processes is transplantation of self tissue. This method is characterized by simplicity, effectiveness and availability which evokes special interest and requires further study.

About the authors

Elena A. Pronina

V.I. Razumovsky Saratov State Medical University; Yu.A. Gagarin Saratov State Technical University

Email: maslyakov@inbox.ru
ORCID iD: 0000-0002-9754-1211
SPIN-code: 8253-3574

MD, PhD, Senior Researcher, Associate Professor of the Central Research Laboratory; Associate Professor

Russian Federation, Saratov

Vladimir V. Maslyakov

«Reaviz» Saratov Medical University

Author for correspondence.
Email: maslyakov@inbox.ru
ORCID iD: 0000-0002-0052-9401
SPIN-code: 4232-3811

MD, PhD, Professor, Head of the Scientific Department

Russian Federation, Saratov

Aleksej N. Ivanov

V.I. Razumovsky Saratov State Medical University

Email: maslyakov@inbox.ru
ORCID iD: 0000-0003-4061-5221
SPIN-code: 3397-1840
ResearcherId: L-5768-2015

MD, PhD, Associate Professor, Head of the Central Research Laboratory

Russian Federation, Saratov

Tat`jana V. Stepanova

V.I. Razumovsky Saratov State Medical University

Email: maslyakov@inbox.ru
ORCID iD: 0000-0001-8439-8033
SPIN-code: 2744-9679

Junior Researcher of the Central Research Laboratory

Russian Federation, Saratov

Jera B. Popyhova

V.I. Razumovsky Saratov State Medical University

Email: maslyakov@inbox.ru
ORCID iD: 0000-0002-7662-4755
SPIN-code: 7810-3930

PhD in Biological Scien-ces, Senior Researcher of the Central Research Laboratory

Russian Federation, Saratov

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Copyright (c) 2019 Pronina E.A., Maslyakov V.V., Ivanov A.N., Stepanova T.V., Popyhova J.B.

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