Email this article Condition of platelet factor of hemostasis system in pathogenesis of chronic periodontitis progression
- Authors: Kondyurova E.V.1, Vlasova T.I.1, Trofimov V.A.1, Vlasov A.P.1, Adamchik R.A.1, Akimov V.V.1, Tashina E.A.1
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Affiliations:
- National Research Mordovia State University
- Issue: Vol 27, No 2 (2019)
- Pages: 209-218
- Section: Original study
- URL: https://journals.rcsi.science/pavlovj/article/view/14545
- DOI: https://doi.org/10.23888/PAVLOVJ2019272209-218
- ID: 14545
Cite item
Abstract
Аim. Тo evaluate the structural and functional condition of platelets as a cellular component of the hemostasis system in chronic generalized periodontitis of different severity, and to establish its role in the progression of the disease.
Materials and Мethods. Clinical studies included 83 patients (47 men and 36 women) with chronic generalized periodontitis, comparable in age and sex, divided into three groups according to the severity of the disease: the first group (n=21) – periodontitis of mild severity; the second group (n=36) – moderate degree of severity; the third group (n=26) – severe periodontitis. Methods of the study included evaluation of the structural and functional characteristics of periodontal tissues, general hygienic condition of the oral cavity, the severity of the inflammatory process according to index parameters; study of microcirculation of periodontal tissues, determination of the evidence of oxidative processes in saliva, blood plasma, platelets, study of lipid composition of platelets.
Results. In chronic generalized periodontitis, pathological changes in the lipid composition of platelet membranes (an increase in the percentage of lysophospholipids and free fatty acids) were associated with systemic activation of oxidative processes and of phospholipase enzyme systems, which was accompanied by an increase in their aggregation activity.The degree of increase in the activity of platelets was associated with the severity of microcirculatory disturbances in the periodontal tissues. The condition of the cellular component of the hemostasis system correlated with the severity of the pathological process in the periodontium. In severe degree of chronic periodontitis, structural and functional changes in platelets were maximal.
Conclusion. In chronic periodontitis, the systemic activation of oxidative processes leads to a modification of the lipid composition of platelet membranes, which contributes to increase in their aggregation activity playing an important role in the induction of hypercoagulation, microcirculation disturbances and progression of inflammation in the periodontal tissues.
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##article.viewOnOriginalSite##About the authors
Evgeniya V. Kondyurova
National Research Mordovia State University
Email: vestnik@rzgmu.ru
ORCID iD: 0000-0001-9586-655X
SPIN-code: 5026-6907
ResearcherId: A-1857-2018
MD, PhD, Associate Professor, Head of the Department of Dentistry of the Medical Institute
Russian Federation, SaranskTat`yana I. Vlasova
National Research Mordovia State University
Author for correspondence.
Email: vap.61@yandex.ru
ORCID iD: 0000-0002-2624-6450
SPIN-code: 5314-3771
ResearcherId: Q-9761-2017
MD, PhD, Professor of the Department of Normal and Pathological Physiology of the Medical Institute
Russian Federation, SaranskVladimir A. Trofimov
National Research Mordovia State University
Email: vestnik@rzgmu.ru
ORCID iD: 0000-0003-1294-1417
SPIN-code: 5131-2399
ResearcherId: С-2221-2017
PhD in Biological Sciences, Professor, Head of the Department of Genetics
Russian Federation, SaranskAleksey P. Vlasov
National Research Mordovia State University
Email: vestnik@rzgmu.ru
ORCID iD: 0000-0003-4731-2952
SPIN-code: 7405-5077
ResearcherId: C-3981-2018
MD, PhD, Professor, Head of the Department of Faculty Surgery
Russian Federation, SaranskRuslan A. Adamchik
National Research Mordovia State University
Email: vestnik@rzgmu.ru
ORCID iD: 0000-0002-3483-288X
SPIN-code: 8313-0634
ResearcherId: G-5414-2018
MD, PhD, Assistant of the Department of Dentistry of the Medical Institute
Russian Federation, SaranskVladimir V. Akimov
National Research Mordovia State University
Email: vestnik@rzgmu.ru
ORCID iD: 0000-0002-5579-3517
SPIN-code: 3413-4532
ResearcherId: Р-2453-2019
PhD Applicant of the Department of Dentistry of the Medical Institute
Russian Federation, SaranskElena A. Tashina
National Research Mordovia State University
Email: vestnik@rzgmu.ru
ORCID iD: 0000-0002-6206-3547
SPIN-code: 5241-1231
ResearcherId: K-6112-2019
PhD-Student of the Department of Faculty Surgery of the Medical Institute
Russian Federation, SaranskReferences
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