Choroidal thickness in normal subjects and in age-related macular degeneration

封面

如何引用文章

全文:

详细

Results of choroidal thickness measurements in 75 healthy subjects of different age groups (123 eyes) are presented as well as those of 35 patients (45 eyes) with age-related macular degeneration. Examinations were performed with a Spectralis optical coherence tomograph using the regimen of Enhanced Depth Imaging (EDI-OCT). A negative dependence between choroidal thickness and age was found (r = -0.78, p < 0.0001). Sub-foveal thickness of the choroid decreases on average by 2.99 µm for every life year. No significant differences in choroidal thickness of age-related macular degeneration patients and that of healthy people of the same age group were found.

作者简介

Yuriy Astakhov

I. P. Pavlov State Medical University of St. Petersburg

Email: astakhov73@mail.ru
MD, doctor of medical science, professor, head of the department of ophthalmology

Svetlana Belekhova

I. P. Pavlov State Medical University of St. Petersburg

Email: beleksv@yandex.ru
Postgraduate student. Department of Ophthalmology

Nikita Dal

I. P. Pavlov State Medical University of St. Petersburg

Email: ndahl@yandex.ru
candidate of medical science, assistant professor. Department of Ophthalmology

参考

  1. Астахов Ю. С., Лисочкина А. Б., Шадричев Ф. Е. Возрастная макулярная дегенерация // Клинические рекомендации. Офтальмология / под ред. Л. К. Мошетовой, А. П. Нестерова, Е. А. Егорова. - М.: ГЭОТАР-Медиа, 2006. - 164 с.
  2. Улитина А. Ю., Измайлов А. С. Оценка толщины хориоидеи при возрастной макулярной дегенерации // Вестник ОГУ. - 2013. - № 4 (153). - 275-279 с.
  3. Chung S. E., Kang S. E., Lee J. H., Kim Y. T. Choroidal thickness in polypoidal choroidal vasculopathy and exudative age-related macular degeneration // Ophthalmology. - 2011. - Vol. 118, N 5. - P. 840-845.
  4. Donald J., Gass M., 1977.
  5. Fujiwara T., Imamura Y., Margolis R., Slakter J. S. et al. Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes // Am. J. Ophthalmol. - 2009. - Vol. 148, N 3. - P. 445-450.
  6. Grunwald J., Metelitsina T., DuPont J., Ying G-S., Maguire M. Reduced foveolar choroidal blood flow in eyes with increasing AMD severity // Invest. Ophthalmol. Vis Sci. - 2005. - Vol. 46. - P. 1033-1038.
  7. Huang D., Swanson E. A., Lin C. P., Schuman J. S., Stinson W. G., Chang W., Hee M. R., FlotteT., GregoryK., PuliafitoC. A., Fujimoto J. G. Optical coherence tomography // Science. - 1991. - Vol. 254 - P. 1178-81.
  8. Imamura Y., Fujiwara T., Margolis R., Spaide R. F. Enhanced depth imaging optical coherence tomography of the choroid in central serous chorioretinopathy // Retina. - 2009. - Vol. 28. - P. 1469-1473.
  9. Jonas J. B., Forster T. M., Steinmetz P., Schlichtenbrede F. C., Harder B. C. Choroidal thickness in age-related macular degeneration //Retina. - 2013.
  10. Klein R., Klein B. E., Jensen S. C., Cruickshanks K. J. The relationship of ocular factors to the incidence and progression of age-related maculopathy // Arch. Ophthalmol. - 1998. - Vol. 116. - P. 278-282.
  11. Margolis R., Spaide R. F. A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes // Am. J. Ophthalmol. - 2009. - Vol. 147, № 5. - P. 811-815.
  12. McCourt E. A., Cadena B. C., Barnett C. J., Ciardella A. P. et al. Measurement of subfoveal choroidal thickness using spectraldomain optical coherence tomography // Ophthalmic Surg. Lasers Imaging. - 2010. - Vol. 41. - P. 28-33.
  13. Povazay B., Hermann B., Unterhuber A. et al. Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients //J. Biomed Opt. - 2007. - Vol. 12, N 4. - 041211.
  14. Stefansson E, Geirsdottir A, Sigurdsson H. Metabolic physiology in age related macular degeneration // Prog. Retin. Eye Res. - 2011. - Vol. 30. - P. 72-80.

版权所有 © Astakhov Y.S., Belekhova S.G., Dal N.Y., 2014

Creative Commons License
此作品已接受知识共享署名 4.0国际许可协议的许可
 


##common.cookie##