Functional rehabilitation of the patient with keratoconus after collagen cross-linking with modified parameters

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This article contains a clinical case of a favorable outcome of treatment of chronic keratoconus by the collagen cross-linking with modified parameters. Possible mechanisms of action of collagen cross-linking on biomechanical and biochemical properties of the cornea are presented as well as survey data and postoperative dynamic monitoring of the patient before and after collagen cross-linking. Reasoning about new ways to perfect standard approaches with the aim of improving the results of the application of this treatment are also given.

作者简介

Sanasar Papayan

First Pavlov State Medical University of St Petersburg

Email: dr.papanyan@yandex.ru
MD, postgraduate research student. Ophthalmology department

Inna Riks

First Pavlov State Medical University of St Petersburg

Email: riks0503@yandex.ru
MD, PhD, assistant professor. Ophthalmology department

Sergey Novikov

First Pavlov State Medical University of St Petersburg

Email: novikov.phd@gmail.ru
MD, DMedSc, professor. Ophthalmology department

参考

  1. Абугова Т.Д. Кератоконус: клиническая лекция для врачей и оптометристов. - СПб.: ООО РА Веко, 2015. - 94 с. [Abugova TD. Keratokonus: klinicheskaya lektsiya dlya vrachey i optometristov. Sant Petersburg: OOO «RA Veko»; 2015. 94 p. (In Russ).]
  2. Папанян С.С., Новиков С.А., и др. Результаты ретроспективного исследования коллагенового кросс-линкинга при кератоконусе на ранних стадиях заболевания // Современная оптометрия. - 2015. - № 10(90). - С. 20-24. [Papanyan SS, Novikov SA, et al. Rezul’taty retrospektivnogo issledovaniya kollagenovogo kross-linkinga pri keratokonuse na rannikh stadiyakh zabolevaniya. Sovremennaya optometriya. 2015;10(90):20-24. (In Russ).]
  3. Elbaz U, Shen C, Lichtinger A. More Accelerated (9-mW/ cm2) Corneal Collagen Crosslinking for Keratoconus-A 1 Year Follow-up. Cornea. 2014;33(8):769-773. doi: 10.1097/ICO.0000000000000154.
  4. Spoerl E, Schreiber J, Hellmund, et al. Crosslinking Effects in the Cornea of Rabbits. Ophthalmology. 2000;97:203-206.
  5. Wollensak G, Spoerl E, Seiler Th. Riboflavin/Ultraviolet-A Induced Collagen Crosslinking for the Treatment of Keratoconus. Am J Ophthalmol. 2003;135:620-627. doi: 10.1016/S0002-9394(02)02220-1.
  6. Wilson SE, Kim WG. Keratocyte Apoptosis: Implication on Corneal Wound Healing, Tissue Organization and Disease. Invest Ophthalmol Vis Sci. 1998;39:220-226.

版权所有 © Papayan S.S., Riks I.A., Novikov S.A., 2016

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