Paracentral acute middle maculopathy: from diagnosis toward clinical perspectives
- Authors: Burnasheva M.A.1, Kulikov A.N.1, Maltsev D.S.1
-
Affiliations:
- S.M. Kirov Military Medical Academy
- Issue: Vol 13, No 4 (2020)
- Pages: 57-66
- Section: Reviews
- URL: https://journals.rcsi.science/ov/article/view/48528
- DOI: https://doi.org/10.17816/OV48528
- ID: 48528
Cite item
Abstract
In this review of literature, we reviewed the current state of knowledge on paracentral acute middle maculopathy (PAMM). The diversity of clinical manifestations, a variety of related cardiovascular and ocular conditions, as well as reported idiopathic cases, allow considering PAMM as a distinct clinical phenomenon or a syndrome. Taking into account already described and potential associations with systemic and ocular morbidity, PAMM may apply for a place of an important clinical biomarker not only for ocular but for systemic disorders in a broad cohort of patients. However, the understanding of the pathophysiology of PAMM and of its actual clinical significance is far from complete, and further studies are warranted.
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##article.viewOnOriginalSite##About the authors
Maria A. Burnasheva
S.M. Kirov Military Medical Academy
Email: maria.andreevna1@gmail.com
MD, ophthalmologist of the ophthalmology department. S.M. Kirov Military Medical Academy
Russian Federation, St. PetersburgAlexei N. Kulikov
S.M. Kirov Military Medical Academy
Email: alexey.kulikov@mail.ru
ORCID iD: 0000-0002-5274-6993
MD, PhD, Dr. Sci. (Med.), assistant professor, head of the ophthalmology department. S.M. Kirov Military Medical Academy
St. PetersburgDmitrii S. Maltsev
S.M. Kirov Military Medical Academy
Author for correspondence.
Email: glaz.med@yandex.ru
ORCID iD: 0000-0001-6598-3982
MD, PhD, Cand. Sci. (Med.), Head of medical retina division of ophthalmology department S.M. Kirov Military Medical Academy
Russian Federation, St. PetersburgReferences
- Bos PJ, Deutman AF. Acute macular neuroretinopathy. Am J Ophthalmol. 1975;80:573-84. https://doi.org/10.1016/0002-9394(75)90387-6
- Sieving PA, Fishman GA, Salzano T, Rabb MF. Acute macular neuroretinopathy: early receptor potential change suggests photoreceptor pathology. Br J Ophthalmol. 1984;68(4):229-234. https://doi.org/10.1136/bjo.68.4.229
- O’Brien DM, Farmer SG, Kalina RE, Leon JA. Acute macular neuroretinopathy following intravenous sympathomimetics. Retina. 1989;9(4): 281-286. https://doi.org/10.1097/00006982-198909040-00008
- Leys M, Van Slycken S, Koller J, Van de Sompel W. Acute macular neuroretinopathy after shock. Bull Soc Belge Ophtalmol. 1991;241:95-104
- Rait JL, O’Day J. Acute macular neuroretinopathy. Aust N Z J Ophthalmol. 1987;15(4):337-340. https://doi.org/10.1111/j.1442-9071. 1987.tb00093.x
- Gass JD, Hamed LM. Acute macular neuroretinopathy and multiple evanescent white dot syndrome occurring in the same patients. Arch Ophthalmol. 1989;107(2):189-193. https://doi.org/ 10.1001/archopht.1989.01070010195021
- Sieving PA, Fishman GA, Salzano T, Rabb MF. Acute macular neuroretinopathy: early receptor potential change suggests photoreceptor pathology. Br J Ophthalmol. 1984;68(4):229-234. https://doi.org/ 10.1136/bjo.68.4.229
- Feigl B, Haas A. Optical coherence tomography (OCT) in acute macular neuroretinopathy. Acta Ophthalmol Scand. 2000;78(6): 714-716. https://doi.org/10.1034/j.1600-0420.2000.078006714.x
- Watzke RC, Shults WT. Annular macular neuroretinopathy and multifocal electroretinographic and optical coherence tomographic findings. Retina. 2004;24(5):772-775. https://doi.org/10.1097/00006982-200410000-00014
- Monson BK, Greenberg PB, Greenberg E, et al. High-speed, ultra-high-resolution optical coherence tomography of acute macular neuroretinopathy. Br J Ophthalmol. 2007;91(1):119-120. https://doi.org/10.1136/bjo.2006.098871
- Hughes EH, Siow YC, Hunyor AP. Acute macular neuroretinopathy: anatomic localisation of the lesion with high-resolution OCT. Eye (Lond). 2009;23(11):2132-2134. https://doi.org/10.1038/eye.2008.430.
- Casalino G, Arrigo A, Romano F, et al. Acute macular neuroretinopathy: pathogenetic insights from optical coherence tomography angiography. Br J Ophthalmol. 2019;103(3):410-414. https://doi.org/10.1136/bjophthalmol-2018-312197
- Sarraf D, Rahimy E, Fawzi AA, et al. Paracentral acute middle maculopathy: a new variant of acute macular neuroretinopathy associated with retinal capillary ischemia. JAMA Ophthalmol. 2013;131(10): 1275-1287. https://doi.org/10.1001/jamaophthalmol.2013.4056
- Michaelson IC, Campbell AC. The anatomy of the finer retinal vessels. Trans Ophthal Soc UK. 1940;60:71-111.
- Shah D, Saurabh K, Roy R. Multimodal imaging in paracentral acute middle maculopathy. Ind J Ophthalmol. 2018;66(8): 1186-1188. https://doi.org/10.4103/ijo.IJO_173_18
- Nakamura M, Katagiri S, Hayashi T, et al. Longitudinal follow-up of two patients with isolated paracentral acute middle maculopathy. Int Med Case Rep J. 2019;12:143-149. Published 2019 May 6. https://doi.org/10.2147/IMCRJ.S196047
- Dansingani KK, Freund KB. Paracentral Acute Middle Maculopathy and Acute Macular Neuroretinopathy: Related and Distinct Entities. Am J Ophthalmol. 2015;160(1):1-3.e2. https://doi.org/10.1016/j.ajo.2015.05.001
- Rahimy E, Sarraf D, Dollin ML, et al. Paracentral acute middle maculopathy in nonischemic central retinal vein occlusion. Am J Ophthalmol. 2014;158(2):372-380.e1. https://doi.org/10.1016/j.ajo.2014.04.024
- Browning DJ. Patchy ischemic retinal whitening in acute central retinal vein occlusion. Ophthalmology. 2002;109(11):2154-2159. https://doi.org/10.1016/s0161-6420(02)01217-4
- Rahimy E, Sarraf D. Paracentral acute middle maculopathy spectral-domain optical coherence tomography feature of deep capillary ischemia. Curr Opin Ophthalmol. 2014;25(3):207-212. https://doi.org/10.1097/ICU.0000000000000045
- Ramtohul P, Freund KB. Central Acute Middle Maculopathy: A Novel Variant of Paracentral Acute Middle Maculopathy in Foveal Hypoplasia. Ophthalmol Retina. 2020;4(3):344-347. https://doi.org/10.1016/j.oret.2019.10.003
- Yu S, Pang CE, Gong Y, et al. The spectrum of superficial and deep capillary ischemia in retinal artery occlusion. Am J Ophthalmol. 2015;159(1):53-63.e2. https://doi.org/10.1016/j.ajo.2014.09.027
- Pichi F, Fragiotta S, Freund KB, et al. Cilioretinal artery hypoperfusion and its association with paracentral acute middle maculopathy. Br J Ophthalmol. 2019;103(8):1137-1145. https://doi.org/10.1136/bjophthalmol-2018-312774
- da Fonseca MLG, Souza A, Pereira MB, et al. Paracentral acute middle maculopathy associated with hypoperfusion of the cilioretinal artery and impending central retinal vein occlusion. Eur J Ophthalmol. 2019;1120672119885787. https://doi.org/10.1177/1120672119885787
- McLeod D. En Face Optical Coherence Tomography Analysis to Assess the Spectrum of Perivenular Ischemia and Paracentral Acute Middle Maculopathy in Retinal Vein Occlusion. Am J Ophthalmol. 2017;182:203-204. https://doi.org/10.1016/j.ajo.2017.06.037
- Chen X, Rahimy E, Sergott RC, et al. Spectrum of Retinal Vascular Diseases Associated With Paracentral Acute Middle Maculopathy. Am J Ophthalmol. 2015;160(1):26-34.e1. https://doi.org/10.1016/j.ajo.2015.04.004
- Rahimy E, Kuehlewein L, Sadda SR, Sarraf D. Paracentral Acute Middle Maculopathy: What We Knew Then and What We Know. Now. Retina. 2015;35(10):1921-1930. https://doi.org/10.1097/IAE.0000000000000785
- Tokimitsu M, Murata M, Toriyama Y, et al. Delineation of capillary dropout in the deep retinal capillary plexus using optical coherence tomography angiography in a patient with Purtscher’s retinopathy exhibiting normal fluorescein angiography findings: a case report. BMC Ophthalmol. 2016;16:113. https://doi.org/10.1186/s12886-016-0298-x
- Sridhar J, Shahlaee A, Shieh WS, Rahimy E. Paracentral acute middle maculopathy associated with retinal artery occlusion after cosmetic filler injection. Retin Cases Brief Rep. 2017;11 Suppl 1: S216-S218. https://doi.org/10.1097/ICB.0000000000000466
- Khatibi A. Brazilian booty retinopathy: purtscher-like retinopathy with paracentral acute middle maculopathy associated with pmma injection into buttocks. Retin Cases Brief Rep. 2018;12(1):17-20. https://doi.org/10.1097/ICB.0000000000000380
- Shah D, Saurabh K, Roy R. Multimodal imaging in paracentral acute middle maculopathy. Ind J Ophthalmol. 2018;66(8): 1186-1188. https://doi.org/10.4103/ijo.IJO_173_18
- Baciu P, Nofar CM, Spaulding J, Gao H. Branch retinal artery occlusion associated with paracentral acute middle maculopathy in a patient with livedo reticularis. Retin Cases Brief Rep. 2017;11(4): 356-360. https://doi.org/10.1097/ICB.0000000000000370
- Trese MG, Thanos A, Yonekawa Y, Randhawa S. Optical Coherence Tomography Angiography of Paracentral Acute Middle Maculopathy Associated with Primary Antiphospholipid Syndrome. Ophthalmic Surg Lasers Imaging Retina. 2017;48(2):175-178. https://doi.org/10.3928/23258160-20170130-13
- Kido A, Uji A, Morooka S, et al. Outer Plexiform Layer Elevations as a Marker for Prior Ocular Attacks in Patients with Behcet’s Disease. Invest Ophthalmol Vis Sci. 2018;59(7):2828-2832. https://doi.org/10.1167/iovs.18-24348
- Carey A, Cohen S. Paracentral acute middle maculopathy in birdshot chorioretinopathy: a novel association. Retin Cases Brief Rep. 2016;10(2):151-153. https://doi.org/10.1097/ICB.0000000000000212.
- Hussnain SA, Coady PA, Stoessel KM. Paracentral acute middle maculopathy: precursor to macular thinning in sickle cell retinopathy. BMJ Case Rep. 2017;2017. https://doi.org/10.1136/bcr-2016-216124
- Ilginis T, Keane PA, Tufail A. Paracentral acute middle maculopathy in sickle cell disease. JAMA Ophthalmol. 2015;133(5):614-616. https://doi.org/10.1001/jamaophthalmol.2014.6098
- Cohen MN, Dang S, Liang MC. Paracentral Acute Middle Maculopathy After Cardiac Arrest. Ophthalmology. 2017;124(4):511. https://doi.org/10.1016/j.ophtha.2016.10.007
- Shahlaee A, Sridhar J, Rahimy E, Shieh WS, Ho AC. Paracentral acute middle maculopathy associated with postviral purtscher-like retinopathy. Retin Cases Brief Rep. 2019;13(1):50-53. https://doi.org/10.1097/ICB.0000000000000529
- Mine I, Taguchi M, Sakurai Y, Takeuchi M. Bilateral idiopathic retinal vasculitis following coxsackievirus A4 infection: a case report. BMC Ophthalmol. 2017;17(1):128. https://doi.org/10.1186/s12886-017-0523-2
- Haskes C, Santapaola S, Zinn J. An Atypical Case of Paracentral Acute Middle Maculopathy. Optom Vis Sci. 2017;94(8):845-850. https://doi.org/10.1097/OPX.0000000000001087
- Chen Y, Hu Y. The optical imaging of idiopathic paracentral acute middle maculopathy in a Chinese young man and review of the literature. Photodiagnosis Photodyn Ther. 2017;19:383-387. https://doi.org/10.1016/j.pdpdt.2017.07.004
- Creese K, Ong D, Sandhu SS, et al. Paracentral acute middle maculopathy as a finding in patients with severe vision loss following phacoemulsification cataract surgery. Clin Exp Ophthalmol. 2017;45(6):598-605. https://doi.org/10.1111/ceo.12945
- Nakashima H, Iwama Y, Tanioka K, Emi K. Paracentral Acute Middle Maculopathy following Vitrectomy for Proliferative Diabetic Retinopathy: Incidence, Risk Factors, and Clinical Characteristics. Ophthalmology. 2018;125(12):1929-1936. https://doi.org/10.1016/j.ophtha.2018.07.006
- Ang MJ, Chen JJ, McDonald HR. Paracentral acute middle maculopathy after epiretinal membrane removal. Retin Cases Brief Rep. 2019. https://doi.org/10.1097/ICB.0000000000000883
- Gascon P, Briantais A, Bertrand E, et al. Covid-19-Associated Retinopathy: A Case Report. Ocul Immunol Inflamm. 2020;28(8): 1293-1297. https://doi.org/10.1080/09273948.2020.1825751
- Virgo J, Mohamed M. Paracentral acute middle maculopathy and acute macular neuroretinopathy following SARS-CoV-2 infection. Eye. 2020;34(12):2352-2353. https://doi.org/10.1038/s41433-020-1069-8
- Sridhar J, Shahlaee A, Rahimy E, et al. Optical Coherence Tomography Angiography and En Face Optical Coherence Tomography Features of Paracentral Acute Middle Maculopathy. Am J Ophthalmol. 2015;160(6):1259-1268.e2. https://doi.org/10.1016/j.ajo.2015.09.016
- Ghasemi Falavarjani K, Phasukkijwatana N, Freund KB, et al. En Face Optical Coherence Tomography Analysis to Assess the Spectrum of Perivenular Ischemia and Paracentral Acute Middle Maculopathy in Retinal Vein Occlusion. Am J Ophthalmol. 2017;177:131-138. https://doi.org/10.1016/j.ajo.2017.02.015
- Garrity ST, Tseng VL, Sarraf D. Paracentral acute middle maculopathy in a perivenular fern-like distribution with en face optical coherence tomography. Retin Cases Brief Rep. 2018;12 Suppl 1: S25-S28. https://doi.org/10.1097/ICB.0000000000000657
- Zhioua Braham I, Kaouel H, Boukari M, et al. OCT-angiography and en-face OCT in paracentral acute middle maculopathy with perivenular ischemia associated with a central retinal artery occlusion [published online ahead of print, 2021 Feb 23]. J Fr Ophtalmol. 2021;S0181-5512(21)00037-1. https://doi.org/10.1016/j.jfo.2020.06.044
- Bakhoum MF, Freund KB, Dolz-Marco R, et al. Paracentral Acute Middle Maculopathy and the Ischemic Cascade Associated With Retinal Vascular Occlusion. Am J Ophthalmol. 2018;195:143-153. https://doi.org/10.1016/j.ajo.2018.07.031
- Nemiroff J, Kuehlewein L, Rahimy E, et al. Assessing Deep Retinal Capillary Ischemia in Paracentral Acute Middle Maculopathy by Optical Coherence Tomography Angiography. Am J Ophthalmol. 2016;162:121-132.e1. https://doi.org/10.1016/j.ajo.2015.10.026
- Nemiroff J, Phasukkijwatana N, Sarraf D. Optical Coherence Tomography Angiography of Deep Capillary Ischemia. Dev Ophthalmol. 2016;56:139-145. https://doi.org/10.1159/000442806
- Iafe NA, Onclinx T, Tsui I, Sarraf D. Paracentral acute middle maculopathy and deep retinal capillary plexus infarction secondary to reperfused central retinal artery occlusion. Retin Cases Brief Rep. 2017;11 Suppl 1: S90-S93. https://doi.org/10.1097/ICB.0000000000000424
- Sellam A, Glacet-Bernard A, Coscas F, Souied EH. [Abnormal retinal artery perfusion and optical coherence tomography angiography (In French)]. J Fr Ophtalmol. 2017;40(5):353-362. https://doi.org/10.1016/j.jfo.2016.12.017
- Phasukkijwatana N, Rahimi M, Iafe N, Sarraf D. Central Retinal Vein Occlusion and Paracentral Acute Middle Maculopathy Diagnosed with En Face Optical Coherence Tomography. Ophthalmic Surg Lasers Imaging Retina. 2016;47(9):862-864. https://doi.org/10.3928/23258160-20160901-10
- Grewal DS, Polascik BA, Kelly MP, Fekrat S. Widefield en face optical coherence tomography to quantify the extent of paracentral acute middle maculopathy. Can J Ophthalmol. 2017;52(3): e85-e88. https://doi.org/10.1016/j.jcjo.2016.11.028
- Casalino G, Williams M, McAvoy C, et al. Optical coherence tomography angiography in paracentral acute middle maculopathy secondary to central retinal vein occlusion. Eye (Lond). 2016;30(6):888-893. https://doi.org/10.1038/eye.2016.57
- Spaide RF, Fujimoto JG, Waheed NK. Image artifacts in optical coherence tomography angiography. Retina. 2015;35(11):2163-2180. https://doi.org/10.1097/IAE.0000000000000765
- Casalino G, Coppola M, Earley O, et al. Paracentral acute middle maculopathy as a cause of unexplained visual loss in central retinal vein occlusion. Saudi J Ophthalmol. 2019;33(2):168-171. https://doi.org/10.1016/j.sjopt.2018.07.005
- Groeneveld E. Paracentral acute middle maculopathy as a finding in patients with severe vision loss following phacoemulsification cataract surgery: comment. Clin Exp Ophthalmol. 2018;46(5): 576-577. https://doi.org/10.1111/ceo.13117
- Hooshmand J, Moore P, McKay D, Vote BJ. Paracentral acute middle maculopathy associated with severe vision loss following vitrectomy for vitreous haemorrhage. Clin Exp Ophthalmol. 2018;46(6):706-708. https://doi.org/10.1111/ceo.13151
- O’Day R, Harper CA, Wickremasinghe SS. Central retinal artery occlusion showing features of paracentral acute middle maculopathy following uncomplicated pterygium surgery. Clin Exp Ophthalmol. 2019;47(1):141-143. https://doi.org/10.1111/ceo.13353
- Pham C, Boo A, Chew SKH, Okada M. Paracentral acute middle maculopathy in a young patient following routine phacoemulsification surgery. Clin Exp Ophthalmol. 2019;47(9):1206-1209. https://doi.org/10.1111/ceo.13597
- Maltsev DS, Kulikov AN, Burnasheva MA, Chhablani J. Prevalence of resolved paracentral acute middle maculopathy lesions in fellow eyes of patients with unilateral retinal vein occlusion. Acta Ophthalmol. 2020;98(1): e22-e28. https://doi.org/10.1111/aos.14196
- Burnasheva MA, Maltsev DS, Kulikov AN, Sherbakova KA, Barsukov AV. Association of Chronic Paracentral Acute Middle Maculopathy Lesions with Hypertension. Ophthalmol Retina. 2020;4(5):504-509. https://doi.org/10.1016/j.oret.2019.12.001
- Casalino G, Williams M, McAvoy C, et al. Optical coherence tomography angiography in paracentral acute middle maculopathy secondary to central retinal vein occlusion. Eye (Lond). 2016;30(6):888-893. https://doi.org/10.1038/eye.2016.57
- Wu JG, Huang ZY, Zhou WY. Paracentral Acute Middle Maculopathy Treated with Acupuncture: A Case Report. Chin J Integr Med. 2020;26(9):709-712. https://doi.org/10.1007/s11655-019-3155-y.
- Özmert E, Arslan U. Management of Deep Retinal Capillary Ischemia by Electromagnetic Stimulation and Platelet-Rich Plasma: Preliminary Clinical Results. Adv Ther. 2019;36(9):2273-2286. https://doi.org/10.1007/s12325-019-01040-2
- Arrigo A, Knutsson KA, Rajabjan F, et al. Combined central retinal vein occlusion and branch retinal artery occlusion treated with intravitreal dexamethasone implant: A case report. Eur J Ophthalmol. 2020;1120672120909181. https://doi.org/10.1177/1120672120909181