Comparative study of paracoagulation tests in acute myocardial infarction

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Abstract

Ethanol, ß-naphthol (test for "fibrinogen B") and protamine sulfate tests, performed simultaneously in the blood plasma of patients with acute myocardial infarction, showed a high degree of correlation with each other, but they differed in sensitivity: ethanol> ß-naphthol> protamine sulfate. Heparin did not distort the results of the ethanol and β-naphthol tests, while the protamine sulfate test results strongly depended on the presence of heparin. The formation of a granular precipitate is not a positive protamine sulfate test and indicates hyperheparinemia. The ethanol test on the basis of data can be recommended to monitor the state of the hemocoagulation system in acute myocardial infarction, including the period of heparin therapy.

About the authors

S. Z. Gabitov

Kazan State Pedagogical University named after V.I. Lenin; Kazan Order of the Red Banner of Labor Medical Institute named after S. V. Kuratova

Author for correspondence.
Email: info@eco-vector.com

Department of Therapy No. 1; Department of Biochemistry

Russian Federation

R. I. Litvinov

Kazan State Pedagogical University named after V.I. Lenin; Kazan Order of the Red Banner of Labor Medical Institute named after S. V. Kuratova

Email: info@eco-vector.com

Department of Therapy No. 1; Department of Biochemistry

Russian Federation

References

Supplementary files

Supplementary Files
Action
1. JATS XML
2. The frequency of positive PN and the concentration of fibrinogen in blood plasma in the dynamics of acute myocardial infarction.

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