Diagnosis and treatment of diffuse liver lesions in mechanical jaundice

The frequency of involvement of the liver in the pathological process, accompanied by significant changes in the resistance of the body, and the unsatisfactory results of the treatment currently lead to an intensified search for new methods and means for the diagnosis and correction of lesions of the hepatoportal system in mechanical jaundice. The complex of changes developing in the liver with extrahepatic cholestasis and manifested in a combination of dystrophic, inflammatory, necrotic and sclerotic processes is well known. At the same time, in this type of pathology, in recent years, violations of immunological regulation have been increasingly noted, often underlying the development of structural and functional liver lesions [5, 6]. However, until now, in clinical practice, mainly biochemical blood tests with very relative reliability are used to assess the degree of involvement of the liver in the pathological process. In particular, we have previously shown that when comparing the functional and morphological indicators of the liver condition in patients with chronic calculous cholecystitis and its complications, a discrepancy between the data of biochemical blood tests and the severity of diffuse organ damage is found in 64%. There are no corresponding functional criteria for altered histophysiological parameters of the liver [2]. In this regard, a detailed comparative analysis of morphological, biochemical, immunological and clinical data obtained in pre and postoperative periods in patients with mechanical jaundice is theoretically and practically justified.