The course of anaphylactic shock against the background of heparin and some aspects of the clinical use of heparin

Heparin is credited with the role of one of the inhibitors of allergic reactions. Hence the attempt by various authors to elucidate the effect of heparin on the development of anaphylactic shock is understandable. VP Kaznacheev (1960) sensitized 25 guinea pigs with the introduction of human serum. For 10-14 minutes. before the introduction of a permissive dose of serum, he injected each pig with heparin intravenously at a dose of 1000-2000 IU per kg of body weight. In 10 minutes. all animals died from anaphylactic shock. It was concluded that heparin does not inhibit the development of anaphylactic shock in guinea pigs.