Y. T. Neishkabh. Comparative Evaluation of Typhoid Therapy in Children's Practice. Physician's Gazette of 1901, No 31

On 23 cases of typhoid fever in children at the age of 8 months. up to 15 liters. The author carried out three methods of treatment: antipyretic - pharmaceutical (antipyrine), water treatment and expectant or symptomatic. The first method was used to treat 5 children aged 4 to 12 years; antipyrine was given regularly in doses from o, s to i, o 3 times a day. According to the author's observations, antipyrine greatly lowers t ° in the first days of the illness and during the weakening of the fever (on the 3rd week and very weakly with the tension of the painful process; the heart becomes more frequent and the pulse is soft, jumping up and slightly resistant (on prolonged action) scarlet rash, sometimes draining.