Development of the drug fibronectin and substantiation of its use to stimulate corneal healing

D. M. Zubairov; Зубаиров Д. М.; I. V. Brikman; Брикман И. В.; O. D. Zinkevich; Зинкевич О. Д.; R. I. Litvinov; Литвинов Р. И.; S. I. Ibadova; Ибадова С. И.; R. T. Isaeva; Исаева Р. Т.; A. F. Harrasov; Харрасов А. Ф.; N. A. Safina; Сафина Н. А.; G. A. Yermolin; Ермолин Г. А.; V. E. Kotelyansky; Котелянский В. Э.; E. E. Efremov; Ефремов Е. Е.; E. V. Arzamastsev; Арзамасцев Е. В.

doi:10.17816/kazmj99767

Development of the drug fibronectin and substantiation of its use to stimulate corneal healing

Authors: Zubairov D.M.¹^,2^,3^,4, Brikman I.V.¹^,2^,3^,4, Zinkevich O.D.¹^,2^,3^,4, Litvinov R.I.¹^,2^,3^,4, Ibadova S.I.¹^,2^,3^,4, Isaeva R.T.¹^,2^,3^,4, Harrasov A.F.¹^,2^,3^,4, Safina N.A.¹^,2^,3^,4, Yermolin G.A.¹^,2^,3^,4, Kotelyansky V.E.¹^,2^,3^,4, Efremov E.E.¹^,2^,3^,4, Arzamastsev E.V.¹^,2^,3^,4
Affiliations:
1. Kurashov Kazan Order of the Red Banner of Labor Medical Institute
2. Kazan Research Institute of Epidemiology and Microbiology, MH RSFSR
3. Moscow Helmholtz Research Institute of Eye Diseases
4. Institute of Experimental Cardiology, All-Russian Academy of Medical Sciences of the USSR
Issue: Vol 70, No 1 (1989)
Pages: 48-50
Section: Articles
URL: https://journals.rcsi.science/kazanmedj/article/view/99767
DOI: https://doi.org/10.17816/kazmj99767
ID: 99767

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Abstract

The urgency of the search for remedies accelerating corneal healing after its accidental and surgical injuries is obvious. In recent years, along with physical factors, some natural and synthetic substances, fibronectin turned out to be among the most promising therapeutic agents. It is an adhesive protein of connective tissue involved in cell attachment to fibrillar substrates, formation of collagen fibers and intercellular substance. Fibronectin and its fragments have chemotactic activity and can accelerate phagocytosis reactions by macrophages and neutrophils, acting as a non-specific opsonin against many exo- and endogenous pathological microparticles. One form of this protein, called plasma fibronectin, is present in blood and has many biological properties in common with tissue fibronectin.

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About the authors

D. M. Zubairov

Kurashov Kazan Order of the Red Banner of Labor Medical Institute; Kazan Research Institute of Epidemiology and Microbiology, MH RSFSR; Moscow Helmholtz Research Institute of Eye Diseases; Institute of Experimental Cardiology, All-Russian Academy of Medical Sciences of the USSR

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Email: info@eco-vector.com
Russian Federation, Kazan; Kazan; Moscow; Moscow