DIC Syndrome in the theory of continuous blood clotting

Disseminated intravascular coagulation (DIC) is the most common disorder of hemocoagulation in clinical practice. It is found in many diseases, since the causes of its development are different. However, all etiological factors (physical, chemical, microbial and viral influences and malignant growth) are pathogenetically mediated through damage to cells and their membranes. Such damage results (usually in combination) in the release of tissue thromboplastin and intracellular proteinases into the bloodstream, as well as exposure of the subendothelium of blood vessels. These three consequences of cell damage act as primary specific initiators of blood coagulation by both external and internal mechanisms.