Retinoic acid preparations in the complex treatment of acute promyelocytic leukemia
- Authors: Cherepanova V.V.1, Medvedeva N.A.1, Tarasova L.N.1, Svedentsov E.P.1, Kudryavtseva A.V.1, Hovsepyan V.A.1, Platonov G.K.1, Minakov V.N.1, Kostin A.I.1
-
Affiliations:
- Кировский НИИ гематологии и переливания крови
- Issue: Vol 81, No 1 (2000)
- Pages: 18-26
- Section: Theoretical and clinical medicine
- URL: https://journals.rcsi.science/kazanmedj/article/view/96225
- DOI: https://doi.org/10.17816/kazmj96225
- ID: 96225
Cite item
Full Text
Abstract
The results of the treatment of 11 patients with acute promyelocyte leukosis using the retinoic acid drugs (ATRA, 13-cis-retinoic acid) are presented. Total remission was achieved in 6 out of 9 patients within 22—39 days of treatment: in 2 patients — on ATRA monotherapy and in 4 patients — in combination with polychemotherapy. Normalization of hemostasis indices with tendency to hypercoagulation is noted during the first week. Cupping of hemorrhages took place within 14—30 days of treatment. High incidence (67%) of the retinoic acid syndrome is noted. It is connected with the initial hyperleukocytosis and not always timely prescription of polychemotherapy. Less dramatic nature of the disease course, fast cupping of hemorrhages, absence of the bone marrow aplasia phase, decrease of demand in transfusional provision were observed in using ATRA.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
V. V. Cherepanova
Кировский НИИ гематологии и переливания крови
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Киров
N. A. Medvedeva
Кировский НИИ гематологии и переливания крови
Email: info@eco-vector.com
Russian Federation, Киров
L. N. Tarasova
Кировский НИИ гематологии и переливания крови
Email: info@eco-vector.com
Russian Federation, Киров
E. P. Svedentsov
Кировский НИИ гематологии и переливания крови
Email: info@eco-vector.com
Russian Federation, Киров
A. V. Kudryavtseva
Кировский НИИ гематологии и переливания крови
Email: info@eco-vector.com
Russian Federation, Киров
V. A. Hovsepyan
Кировский НИИ гематологии и переливания крови
Email: info@eco-vector.com
Russian Federation, Киров
G. K. Platonov
Кировский НИИ гематологии и переливания крови
Email: info@eco-vector.com
Russian Federation, Киров
V. N. Minakov
Кировский НИИ гематологии и переливания крови
Email: info@eco-vector.com
Russian Federation, Киров
A. I. Kostin
Кировский НИИ гематологии и переливания крови
Email: info@eco-vector.com
Russian Federation, Киров
References
Supplementary files
