The effect of dicoumarin on some parameters of the blood coagulation system in the treatment of patients with myocardial infarction

Currently, the use of anticoagulants in myocardial infarction reduces mortality, reduces the number of thromboembolic complications and improves the course of the disease (B. P. Kushelevsky, D. M. Grozdov, V. A. Agranenko, B. V. Konyaev). Although the literature on anticoagulants is extensive, the question of their influence on individual factors of the blood coagulation system remains not sufficiently illuminated. Anticoagulant therapy in most cases is controlled by determining the prothrombin index. However, the state of the blood coagulation system depends not only on the prothrombin activity of the blood (A. A. Bagdasarov et al., V. P. Baluda, A. Ya. Yaroshevsky et al., Et al.). Sometimes, with high prothrombin activity during treatment with dicoumarin, bleeding is possible, with a low content of prothrombin in the blood - thromboembolic complications.