Clinicolaboratory characteristic of nervous system state in herpetic neuroinfection in newborns

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Abstract

The combined examination of nervous system including echography, electroencephalography, caused potentials, dopplerography of brain vessels, scintigraphy in 10 newborns with herpetic encephalitis is performed. The disease begins intrauterinely in 2 children, after birth — in 8 children. The inspecificity of the clinical picture and changes of bioelectrical activity in this disease is shown. The acute initial part of the disease originated in spasms, the decrease of cerebral activity coincidentally with detection of focal and diffusive increase of echogenicity of hemispheres provide reason enough to perform virologic examination as well as for the purpose of peculiar antiherpetic therapy.

About the authors

I. I. Kudashov

Russian Research Center for Perinatology, Obstetrics and Gynecology Russian Academy of Medical Sciences

Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Moscow

A. M. Kazmin

Russian Research Center for Perinatology, Obstetrics and Gynecology Russian Academy of Medical Sciences

Email: info@eco-vector.com
Russian Federation, Moscow

I. V. Orlovskaya

Russian Research Center for Perinatology, Obstetrics and Gynecology Russian Academy of Medical Sciences

Email: info@eco-vector.com
Russian Federation, Moscow

I. I. Maltseva

Russian Research Center for Perinatology, Obstetrics and Gynecology Russian Academy of Medical Sciences

Email: info@eco-vector.com
Russian Federation, Moscow

L. K. Ebralidze

Russian Research Center for Perinatology, Obstetrics and Gynecology Russian Academy of Medical Sciences

Email: info@eco-vector.com
Russian Federation, Moscow

O. E. Ozerova

Russian Research Center for Perinatology, Obstetrics and Gynecology Russian Academy of Medical Sciences

Email: info@eco-vector.com
Russian Federation, Moscow

N. V. Ivanova

Russian Research Center for Perinatology, Obstetrics and Gynecology Russian Academy of Medical Sciences

Email: info@eco-vector.com
Russian Federation, Moscow

N. I. Dmitrienkova

Russian Research Center for Perinatology, Obstetrics and Gynecology Russian Academy of Medical Sciences

Email: info@eco-vector.com
Russian Federation, Moscow

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2. Fig. 1. Echographic picture of the brain in acute herpetic encephalitis: a - an echogram of the brain of a healthy newborn, b - a diffuse increase in the echogenicity of the frontal and temporal lobes of the cerebral hemispheres in a child with herpetic encephalitis (2 weeks of age).

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3. Fig. 2. Encephaloscintigram and curves "activity - time" in herpetic encephalitis: a - data of a newborn child without brain damage; b - an increase in the time of arterial and venous phases in a newborn with herpetic encephalitis (2 weeks of life).

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4. Fig. 3. Changes in cerebral blood flow in herpetic encephalitis: a - Doppler ultrasound of a healthy newborn, b - the absence of diastolic blood flow velocity in the main artery of the brain in a newborn with herpetic encephalitis (according to transcranial Doppler ultrasonography).

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