Pathogenetic therapy of hemorrhagic vasculitis occurring with renal syndrome

Kidney damage in hemorrhagic vasculitis, according to clinical and morphological studies, is observed in 23.8-66.0% of patients [1, 4, 6] the gas of the renal syndrome in hemorrhagic vasculitis is considered as a result of damage to the walls of the microvessels of the organ by antigen-antibody complexes and activated components of the complement system. Hemocoagulation disorders in this disease have the character of increased local and diffuse blood clotting [3-4]. Many issues related to the treatment of patients with hemorrhagic vasculitis with renal syndrome are solved ambiguously. Along with the use of corticosteroids as part of pathogenetic therapy [4], a negative attitude is expressed towards them [5], motivated by the fact that steroid therapy has a beneficial effect on skin-joint, abdominal syndromes and is ineffective in the renal process, including the development of nephrotic syndrome. An increase in hypertension and hematuria under the influence of corticosteroids is described. It is emphasized that kidney damage in hemorrhagic vasculitis is less treatable than nephritis against the background of other systemic diseases [5J.