Mitotic disorders in diphtheria intoxication
- Authors: Gazizova G.R.1
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Affiliations:
- Kazan Research Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Soviet Federative Socialist Republic
- Issue: Vol 65, No 2 (1984)
- Pages: 145-148
- Section: Theoretical and clinical medicine
- URL: https://journals.rcsi.science/kazanmedj/article/view/89083
- DOI: https://doi.org/10.17816/kazmj89083
- ID: 89083
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Abstract
In the extensive literature on the pathomorphology of diphtheria, we did not find information about the effect of diphtheria toxin on mitosis in the affected tissues. Only in one of the works devoted to the description of the cytotoxic effect of the toxin on tissue culture was the disappearance of mitotic figures in an intoxicated cell culture noted [5].
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##article.viewOnOriginalSite##About the authors
G. R. Gazizova
Kazan Research Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Soviet Federative Socialist Republic
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Kazan
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Fig. 1. Influence of diphtheria toxin on mitosis in cultured transplanted human FL amniotic epithelium. Designations: thin line - mitotic index (MI), intermittent pathological mitoses (PM), thickened - cytotoxic effect (CTE), columns with dots - prophases, with beveled lines - metaphases, filled - anaphases, with crossed lines - telophases.
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Fig. 2. Pathological forms of mitosis to the outcome of diphtheria intoxication of FL cells at different doses of the toxin. Designations: columns with beveled lines - swelling and adhesion of chromosomes, with dots - lagging chromosomes, with cross lines - disintegration of crumpled chromosomes (karyorrhexis).
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Fig. 3. Pathological forms of mitosis in case of diphtheria intoxication of FL cell culture (40 CTD50, 3 h). Hematoxylin-eosin staining. X 1440. Designations: A - metaphase with swelling, adhesion and lagging of chromosomes; B - early anaphase with the disintegration of the stuck together swollen chromosomes by the formation of a micro nucleus; B - fragmentation of chromosomes - in metaphase; D - karyorrhexis and pyknotization in the telophase.
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