Isozymes and total activity of lactate dehydrogenase in erythrocytes of children with overt and latent diabetes mellitus

The total activity of lactate dehydrogenase and its isoenzymes in erythrocytes of 62 children with diabetes mellitus and 40 children with a latent form of its course was studied. In the stage of decompensation of diabetes mellitus, the total activity of lactate dehydrogenase is significantly reduced, and in the state of compensation of carbohydrate metabolism, it is increased. An increase in the total activity of lactate dehydrogenase was also revealed in the latent course of diabetes. The spectrum of isoenzymes of lactate dehydrogenase in the process of clinical and metabolic compensation of the disease is shifted towards cathode fractions. Under the influence of insulin treatment in combination with biguanides, there is a significant increase in the 4th fraction of lactate dehydrogenase.