The content of free amino acids in blood serum in chronic myeloid leukemia and idiopathic myelofibrosis

The results of studies of the content of free amino acids in blood serum in patients with chronic myeloid leukemia and idiopathic myelofibrosis are analyzed. In chronic myeloid leukemia, the level of methionine +-valine, leucine + isoleucine was reduced, and cystine, serine and glycine were elevated. With myelofibrosis, a decrease in the concentration of lysine, histidine, arginine and to a lesser extent methionine + valine, aspartic acid and serine was found. The content of alanine, glutamic acid, and cysteine is increased. The nature of metabolic disorders of amino acids in the blood serum in these diseases, along with similarities, has fairly clear differences. The specificity of the latter in combination with other signs may become one of the early biochemical criteria for the differential diagnosis of chronic myeloid leukemia and myelofibrosis.