Concentration of antimicrobic antibodies in children with diabetes mellitus of the 1st type

Abstract

The state of antibacterial humoral immunity in 121 children with diabetes mellitus of the 1st type is shown using the hard phase immunoenzymic analysis. The increase of the level of antibodies to glycolipid independent of the degree of carbohydrate metabolism is revealed. The analysis of concentration of E. coli antibodies showed the changes similar to antibodies to glycolipid. Increas in the levels of glycolipid and E. coli antibodies in children with diabetes mellitus of the 1st type is justified by the excess supply of endotoxin from the enteric tract and is the result of its immunogenic properties.

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