Determination of the concentration of circulating immune complexes, immunoglobulin E and G and histamine in the blood and lymph in experimental anaphylactic shock and Arthus phenomenon
- Authors: Alieva TR1
-
Affiliations:
- Azerbaijan Medical University
- Issue: Vol 99, No 1 (2018)
- Pages: 59-63
- Section: Experimental medicine
- URL: https://journals.rcsi.science/kazanmedj/article/view/7810
- DOI: https://doi.org/10.17816/KMJ2018-059
- ID: 7810
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Abstract
Aim. Study of the concentration changes of circulating immune complexes, immunoglobulin E and G and histamine in the blood and lymph in experimental anaphylactic shock and Arthus phenomenon.
Methods. Experiments were conducted on 27 chinchilla rabbits in two series. The studied levels of circulating immune complexes, histamine and immunoglobulin E and G in the blood and lymph of intact animals were used as a control.
Results. The level of histamine in anaphylactic shock increases by 3.8 times, while the level of immunoglobulin E and G increases by 14.7 and 3.5 times compared to intact animals, and the concentration of circulating immune complexes increases to 23 mmol/l during the same period. In Arthus phenomenon the level of immunoglobulin E in the blood increases by 1.3 times, and immunoglobulin G level increases by 4.3 times. The concentration of circulating immune complexes increases by 11.8 times, histamine level raises by 3.5 times compared to intact animals.
Conclusion. The concentration of circulating immune complexes increases both in anaphylactic shock and in Arthus phenomenon; immunoglobulin levels change in different ways: in anaphylactic shock an increase of immunoglobulin E level and decrease of immunoglobulin G level occur, while in Arthus phenomenon, to the contrary, an increase of immunoglobulin G level and decrease of immunoglobulin E level are observed; histamine level increases both in anaphylactic shock and in Arthus phenomenon, however, more significantly in anaphylactic shock; in both allergic reactions the role of circulating immune complexes in the increase of histamine concentration is not excluded, but apparently, the key role is given to immunoglobulin E.
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##article.viewOnOriginalSite##About the authors
T R Alieva
Azerbaijan Medical University
Author for correspondence.
Email: tarana-aliyeva-2016@mail.ru
Baku, Azerbaijan
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