Diagnostic criteria for glanzmann thrombasthenia

Based on long-term observations and study of the state of hemostasis in 17 patients with Glanzmann's thrombasthenia, the diagnostic criteria of this disease during periods of exacerbation and clinical remission were determined. During the period of exacerbation, such signs are violations of platelet adhesion to glass fiber, their aggregation under the influence of ADP, adrenaline and collagen, changes in the excretory reactions of the patient's platelets under the action of ADP on them, as well as a sharp violation of the process of retraction of a blood clot. In the absence of clinical manifestations of the disease, impaired adhesion of platelets to fiberglass, aggregation of platelets under the influence of ADP and adrenaline, as well as a significant decrease in values ​​in retraction of a blood clot retain their diagnostic value.