About hexenal and evipan anesthesia

The idea of ​​introducing narcotic substances into the bloodstream in order to obtain anesthesia appeared long before the use of ether and chloroform for inhalation anesthesia. Scheel reports on the work of Elsgolts, which appeared in 1665. This author succeeded by intravenous administration of opium preparations to achieve anesthesia satisfactory for that time. In 1845, Florence used intravenous chloral in dogs. After the discovery of the narcotic properties of ether, they tried to use it for intravenous anesthesia in order to avoid those unpleasant phenomena associated with the inhalation method of its use. Burcktardt was the first to propose to use ether intravenously and was the first to apply this method in practice. Kümmel proposed a combination of ether with isopral. Ogier in 1875 reported 51 cases of successful anesthesia with intravenous chloral in humans. In our country, Kravkov was offered hedonal and applied in the clinic by prof. Fedorov.