On the question of the pharmacodynamics of spermine in the treatment of pregnancy toxicosis

Currently, clinical and experimental data provide an installation for the search for the root cause of toxicosis in the egg (placenta), and even closer in a foreign agent that has invaded the female body and disturbed its metabolism. In this focus, the statements of the overwhelming majority of authors converge, and this is an absolutely reliable position at the present level of our knowledge. We can only talk about the nature of the impact of the agent itself. Poisoning of the body with the products of interstitial protein breakdown, flowing under the sign of an anaphylactic state, is the construction made shortly before the World War by Ponston, Wold-Eisner, Wertes and Franz. In 1929, regardless of the conclusions of Western European researchers unknown to us, we set about developing the anaphylactic nature of toxicosis and came close to developing a method of anti-anaphylaxis.