Comparative analysis of the systemic inflammatory response in rheumatic diseases

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Abstract

Aim. To compare the course of chronic systemic inflammation during various rheumatic diseases. Methods. Examined were three groups of patients: with ankylosing spondylitis - 25 people (20 males and 5 females), with rheumatoid arthritis - 26 people (11 males and 15 females) and with systemic lupus erythematosus - 49 people (3 males and 46 females). The control group included 50 practically healthy individuals (26 males and 24 females). Analyzed were the following parameters: the content of interleukin-6, -8, -10, C-reactive protein. The integral index of the reactivity coefficient was calculated. Results. The level of the studied cytokines was significantly higher in systemic lupus erythematosus, than in ankylosing spondylitis and rheumatoid arthritis, while the content of C-reactive protein was significantly higher in ankylosing spondylitis and rheumatoid arthritis. The values of the reactivity coefficient were also significantly higher in systemic lupus erythematosus. Conclusion. The presence of systemic inflammation was determined in most patients with systemic lupus erythematosus, while ankylosing spondylitis and rheumatoid arthritis were characterized only by mild manifestations of systemic inflammatory response.

About the authors

D V Ivanov

Ural State Medical Academy, Ekaterinburg

Email: stygminum@yandex.ru

L A Sokolova

Ural State Medical Academy, Ekaterinburg

E Yu Gusev

Institute of Immunology and Physiology of the Ural branch of the Russian Academy of Sciences RAS, Ekaterinburg

L N Kamkina

Regional Clinical Hospital № 1, Ekaterinburg

N O Plekhanova

Central City Clinical Hospital № 6, Ekaterinburg

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© 2012 Ivanov D.V., Sokolova L.A., Gusev E.Y., Kamkina L.N., Plekhanova N.O.

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