Influence of iron sulfate on adipose tissue endocrine dysfunction in Wistar rats
- Authors: Tinkov AA1, Popova EV1, Nikonorov AA1
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Affiliations:
- Orenburg State Medical Academy, Orenburg, Russia
- Issue: Vol 94, No 5 (2013)
- Pages: 760-763
- Section: Actual problems of biochemistry and laboratory diagnostics
- URL: https://journals.rcsi.science/kazanmedj/article/view/1938
- DOI: https://doi.org/10.17816/KMJ1938
- ID: 1938
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Abstract
Aim. To study the adipose tissue endocrine function at adipogenic effect development in Wistar rats on high-fat diet and increased iron intake with drinking water. Methods. Animals on standard and high-fat diets were administered 3 mg/l of iron sulfate with drinking water during 3 months. Levels of circulating proinflammatory cytokines (monocyte chemoattractant protein 1, tumor necrosis factor alpha), leptin, adiponectin, serum glucose and insulin, as well as morphometric parameters and iron content in hair and adipose tissue were evaluated. Results. A significant increase in morphometric parameters, hair iron levels was observed in rats taking iron salts compared to the controls, with highest adipose tissue iron level in rats on high-fat diet. At the same time, serum levels of proinflammatory cytokines (monocyte chemoattractant protein 1, tumor necrosis factor alpha) and leptin was also higher in rats obtaining iron with drinking water compared to controls. Increased serum insulin level together with slightly elevated serum glucose level indicated insulin resistance development in rats on high-fat diet, fed with iron. Conclusion. The research shows that, on the one side, iron intake potentiates the adipogenic effect of high-fat diet, and on the other side, acting as a trigger for endocrine dysfunction formation (so called endocrine disruptor).
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##article.viewOnOriginalSite##About the authors
A A Tinkov
Orenburg State Medical Academy, Orenburg, Russia
E V Popova
Orenburg State Medical Academy, Orenburg, Russia
A A Nikonorov
Orenburg State Medical Academy, Orenburg, Russia
Email: nikonorov_all@mail.ru
References
- Baillie-Hamilton P.F. Chemical toxins: a hypothesis to explain the global obesity epidemic // J. Altern. Complement. Med. - 2002. - Vol. 8. - P. 185-192.
- Dandona P., Aljada A., Bandyopadhyay A. Inflammation: the link between insulin resistance, obesity and diabetes // Trends Immunol. - 2004. - Vol. 25,N 1. - P. 4-7.
- Das U.N. Is obesity an inflammatory condition? // Nutrition. - 2001. - Vol. 17,N 11-12. - P. 953-966.
- Hajer G.R., van Haeften T.W., Visseren F.L. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases // Eur. Heart J. - 2008. - Vol. 29,N 24. - P. 2959-2971.
- Mullerova D., Kopecky J. White adipose tissue: storage and effector site for environmental pollutants // Physiol. Res. - 2007. - Vol. 56. - P. 375-381.
- Novelli E.L., Diniz Y.S., Galhardi C.M. et al. Anthropometrical parameters and markers of obesity in rats // Lab. Anim. - 2007. - Vol. 41,N 1. - P. 111-119.
- Weisberg S.P., McCann D., Desai M. et al. Obesity is associated with macrophage accumulation in adipose tissue // J. Clin. Invest. - 2003. - Vol. 112,N 12. - P. 1796-1808.
- Zekanowska E., Boinska J., Giemza-Kucharska P., Kwapisz J. Obesity and iron metabolism // Biotechnologia. - 2011. - Vol. 92. - P. 147-152.