Analysis of the effect of immunosuppressive therapy on the progression of chronic kidney disease with mesangioproliferative nephritis
- Authors: Sigitova ON1, Kim TY.1, Sineglazova AV1, Kamasheva GR1, Nadeeva RA1
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Affiliations:
- Kazan State Medical University
- Issue: Vol 101, No 2 (2020)
- Pages: 175-181
- Section: Theoretical and clinical medicine
- URL: https://journals.rcsi.science/kazanmedj/article/view/19111
- DOI: https://doi.org/10.17816/KMJ2020-175
- ID: 19111
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Abstract
Aim. To assess the effect of immunosuppressive cyclophosphamide therapy and its regimens on the rate of progression of chronic kidney disease in mesangioproliferative glomerulonephritis.
Methods. 72 patients with mesangioproliferative glomerulonephritis and indications for immunosuppressive therapy with disease activation were included in the comparative analysis: 56 patients received cyclophosphan in conventional doses (26 patients with daily or every other day, 30 patients with in pulse mode 1 time per month), and 16 patients did not receive cyclophosphan. Duration of the disease before observation ranged from 0 to 33.58 years, a median follow-up was 6.00 (interquartile range 1.63–13.17) years, and after observation from 0 to 5 years with the median follow-up was 2.00 (1.00–3.50) years. The examination included nephrobiopsia with a morphological diagnosis, activity index/sclerosis, and glomerulonephritis progression rate for decreased glomerular filtration rate (ml/min/1.73 m² per year).
Results. The progression rate of chronic kidney disease was higher in the group of patients not receiving immunosuppressive therapy, 5.57 (3.27–7.95) ml/min/1.73 m2 per year compared with of the treated patients group, 3.05 (2.04–6.78) ml/min/1.73 m2 per year (p=0.040). There were no differences in the rate of decrease in glomerular filtration rate between groups depending on the treatment regimen: 4.86 (2.12–6.77) ml/min/1.73 m2 per year with regular and 3.67 (2.04– 6.91) ml/min/1.73 m2 per year with a pulse mode (p=0.720). The rate of glomerulonephritis also did not differ significantly: 1.0 (1.0–2.0) and 2.0 (1.0–2.0) relapses over 5 years, respectively (p=0.691) in both treatment regimens.
Conclusion. The treatment of patients with mesangioproliferative glomerulonephritis with cyclophosphane, in combination with prednisone or without it, regardless of the treatment regimen induces a slowdown in the progression of chronic kidney disease, improving the long-term prognosis and without affecting the frequency of relapses of the disease.
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##article.viewOnOriginalSite##About the authors
O N Sigitova
Kazan State Medical University
Author for correspondence.
Email: osigit@rambler.ru
SPIN-code: 3424-7909
Russian Federation, Kazan, Russia
T Yu Kim
Kazan State Medical University
Email: osigit93@gmail.com
ORCID iD: 0000-0003-2370-2972
SPIN-code: 8560-4702
Scopus Author ID: 57208906994
Russian Federation, Kazan, Russia
A V Sineglazova
Kazan State Medical University
Email: osigit93@gmail.com
ORCID iD: 0000-0002-7951-0040
SPIN-code: 4196-1651
Scopus Author ID: 55001894700
Russian Federation, Kazan, Russia
G R Kamasheva
Kazan State Medical University
Email: osigit93@gmail.com
SPIN-code: 1245-3205
Russian Federation, Kazan, Russia
R A Nadeeva
Kazan State Medical University
Email: osigit93@gmail.com
SPIN-code: 4011-8150
Russian Federation, Kazan, Russia
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