Adipose tissue dysfunction markers in obese patients with obstructive sleep apnea syndrome
- Authors: Yakovlev AV1,2, Mayanskaya SD3, Vergazova AN1, Plutalova LP1, Mazina PB1, Mayanskaya NN3, Yakovleva NF2
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Affiliations:
- Railroad Clinical Hospital of the Main Novosibirsk Railway Station, JSCo «Russian Railways», Novosibirsk, Russia
- Novosibirsk State Medical University, Novosibirsk, Russia
- Kazan State Medical University, Kazan, Russia
- Issue: Vol 96, No 2 (2015)
- Pages: 134-137
- Section: Theoretical and clinical medicine
- URL: https://journals.rcsi.science/kazanmedj/article/view/1728
- DOI: https://doi.org/10.17750/KMJ2015-134
- ID: 1728
Cite item
Full Text
Abstract
Aim. To examine the relationship between obstructive sleep apnea syndrome and metabolic dysfunction in obese patients.
Methods. The study included 66 male patients aged 53±5.11 years with previously diagnosed obstructive sleep apnea syndrome and obesity (body mass index ≥30 kg/m2). Cardiorespiratory monitoring, 24-hour blood pressure monitoring was performed in all patients; low density lipoprotein, triglycerides, high density lipoprotein, total cholesterol and glucose blood levels, as well as adiponectin and leptin blood concentrations were measured in all patients.
Results. Blood pressure level and leptin blood concentration were significantly higher in patients with severe form of obstructive sleep apnea syndrome. There was no statistically significant relationship found between the lipid profile parameters and other adipokines and the severity of obstructive sleep apnea syndrome. The data analysis also revealed association between the elevated levels of leptin and the classic cardiovascular risk factors - arterial hypertension and low density lipoprotein level.
Conclusion. The revealed associations may indicate the additional role of leptin as the biochemical marker of early development of obstructive breathing sleep disorders in patients with abdominal obesity, as well as the early manifestation of other components of metabolic syndrome - arterial hypertension and dyslipidemia with concomitant significant increase in cardiovascular risk.
About the authors
A V Yakovlev
Railroad Clinical Hospital of the Main Novosibirsk Railway Station, JSCo «Russian Railways», Novosibirsk, Russia; Novosibirsk State Medical University, Novosibirsk, Russia
Author for correspondence.
Email: alex-yak-card@mail.ru
S D Mayanskaya
Kazan State Medical University, Kazan, Russia
Email: alex-yak-card@mail.ru
A N Vergazova
Railroad Clinical Hospital of the Main Novosibirsk Railway Station, JSCo «Russian Railways», Novosibirsk, Russia
Email: alex-yak-card@mail.ru
L P Plutalova
Railroad Clinical Hospital of the Main Novosibirsk Railway Station, JSCo «Russian Railways», Novosibirsk, Russia
Email: alex-yak-card@mail.ru
P B Mazina
Railroad Clinical Hospital of the Main Novosibirsk Railway Station, JSCo «Russian Railways», Novosibirsk, Russia
Email: alex-yak-card@mail.ru
N N Mayanskaya
Kazan State Medical University, Kazan, Russia
Email: alex-yak-card@mail.ru
N F Yakovleva
Novosibirsk State Medical University, Novosibirsk, Russia
Email: alex-yak-card@mail.ru
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