Efficacy and safety of allergen-specific immunotherapy in children

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Abstract

Atopic diseases are one of the most common chronic diseases in children and adolescents. They lead to a significant deterioration in the quality of life of patients and their families. The only strategy for the treatment of atopic diseases that has a disease-modifying effect is allergen-specific immunotherapy. The purpose of this review is to summarize the literature data on the practical aspects of allergen-specific immunotherapy use in children and adolescents with allergic rhinoconjunctivitis and atopic bronchial asthma. An analysis of scientific articles has shown that allergen-specific immunotherapy can reduce the severity of symptoms of allergic rhinoconjunctivitis and/or atopic bronchial asthma and reduce the amount of pharmacotherapy, as well as reduce the risk of bronchial asthma developing in patients with allergic rhinoconjunctivitis. The current evidence of the preventive effect of allergen-specific immunotherapy in relation to the development of new sensitizations in monosensitized patients is unconvincing, and, according to many authors, new randomized clinical trials are needed. According to most experts, allergen-specific immunotherapy should be started in children from 5 years of age in the presence of proven immunoglobulin E-mediated sensitization to one or more allergens, carried out for at least 3 years, using preparations in which the presence of major allergens is documented. At the same time, both subcutaneous and sublingual administration of allergens has comparable effectiveness. Allergen-specific immunotherapy is a safe and well-tolerated treatment for children, but currently there is no generally accepted classification of possible adverse events, as well as a standardized and uniform system for assessing their severity.

About the authors

Viktoria Y. Delian

Kazan State Medical Academy — branch of the Russian Medical Academy of Postgraduate Education

Author for correspondence.
Email: viktoria_delyan@mail.ru
ORCID iD: 0000-0001-6816-4253

M.D., Cand. Sci. (Med.), Assoc. Prof., Depart. of Allergology and Immunology

Russian Federation, Kazan, Russia

References

  1. Allergologiya i klinicheskaya immunologiya. Klinicheskie rekomendatsii. (Allergology and clinical immunology. Clinical guidelines.) Khaitova RM, Ilina NI, editors. Moscow: GEOTAR-Media; 2019. 337 p. (In Russ.)
  2. Karakoc-Aydiner E, Eifan AO, Baris S, Gunay E, Akturk E, Akkoc T, Bahceciler NN, Barlan IB. Long-term effect of sublingual and subcutaneous immunotherapy in dust mite-allergic children with asthma/rhinitis: A 3-year prospective randomized controlled trial. J Investig Allergol Clin Immunol. 2015;25(5):334–342. PMID: 26727762.
  3. Valovirta E, Petersen TH, Piotrowska T, Laursen MK, Andersen JS, Sørensen HF, Klink R; GAP investigators. Results from the 5-year SQ grass sublingual immunotherapy tablet asthma prevention (GAP) trial in children with grass pollen allergy. J Allergy Clin Immunol. 2018;141(2):529–538.e13. PMID: 28689794. doi: 10.1016/j.jaci.2017.06.014.
  4. Shin JU, Kim SH, Noh JY, Kim JH, Kim HR, Jeong KY, Park KH, Lee J, Chu H, Lee JH, Yong TS, Park JW, Lee KH. Allergen-specific immunotherapy induces regulatory T cells in an atopic dermatitis mouse model. Allergy. 2018;73(9):1801–1811. doi: 10.1111/all.13465.
  5. Smaldini PL, Trejo F, Cohen JL, Piaggio E, Docena GH. Systemic IL‐2/anti‐IL‐2Ab complex combined with sublingual immunotherapy suppresses experimental food allergy in mice through induction of mucosal regulatory T cells. Allergy. 2018;73(4):885–895. doi: 10.1111/all.13402.
  6. Bachmann MF, Kundig TM. Allergen‐specific immunotherapy: is it vaccination against toxins after all? Allergy. 2017;72(1):13–23. doi: 10.1111/all.12890.
  7. Van de Veen W, Stanic B, Yaman G, Wawrzyniak M, Söllner S, Akdis DG, Rückert B, Akdis CA, Akdis M. IgG4 production is confined to human IL-10-producing regulatory B cells that suppress antigen-specific immune responses. J Allergy Clin Immunol. 2013;131(4):1204–1212. doi: 10.1016/j.jaci.2013.01.014.
  8. Van de Veen W. The role of regulatory B cells in allergen immunotherapy. Curr Opin Allergy Clin Immunol. 2017;17(6):447–452. doi: 10.1097/ACI.0000000000000400.
  9. Mösges R, Koch AF, Raskopf E, Singh J, Shah-Hosseini K, Astvatsatourov A, Hauswald B, Yarin Y, Corazza F, Haazen L, Pirotton S, Allekotte S, Zadoyan G, Legon T, Durham SR, Shamji MH. Lolium perenne peptide immunotherapy is well tolerated and elicits a protective B-cell response in seasonal allergic rhinitis patients. Allergy. 2018;73(6):1254–1262. PMID: 29322510. doi: 10.1111/all.13392.
  10. Gordon JR, Ma Y, Churchman L, Gordon SA, Dawicki W. Regulatory dendritic cells for immunotherapy in immunologic diseases. Front Immunol. 2014;5:7. doi: 10.3389/fimmu.2014.00007.
  11. Sun W, Wei JW, Li H, Wei FQ, Li J, Wen WP. Adoptive cell therapy of tolerogenic dendritic cells as inducer of regulatory T cells in allergic rhinitis. International Forum of Allergy & Rhinology. 2018;8(11):1291–1299. doi: 10.1002/alr.22217.
  12. De Aragão-França LS, Aragão-França LS, Rocha VCJ, Rocha VCJ, Cronemberger-Andrade A, da Costa FHB, Costa FHB, Vasconcelos JF, Vasconcelos JF, Athanazio DA, Silva DN, Santos ES, Santos ES, Meira CS, Araujo CF, Araújo CF, Cerqueira JV, Cardillo F, Alcântara-Neves NM, Soares MBP, Pontes de Carvalho LC, Pontes-de-Carvalho LC. Tolerogenic dendritic cells reduce airway inflammation in a model of dust mite triggered allergic inflammation. Allergy Asthma Immunol Res. 2018;10(4):406–419. doi: 10.4168/aair.2018.10.4.406.
  13. Morita H, Kubo T, Rückert B, Ravindran A, Soyka MB, Rinaldi AO, Sugita K, Wawrzyniak M, Wawrzyniak P, Motomura K, Tamari M, Orimo K, Okada N, Arae K, Saito K, Altunbulakli C, Castro-Giner F, Tan G, Neumann A, Sudo K, O'Mahony L, Honda K, Nakae S, Saito H, Mjösberg J, Nilsson G, Matsumoto K, Akdis M, Akdis CA. Induction of human regulatory innate lymphoid cells from group innate lymphoid cells by retinoic acid. J Allergy Clin Immunol. 2019;143(6):2190–2201.e9. doi: 10.1016/j.jaci.2018.12.1018.
  14. Wang S, Xia P, Chen Y, Qu Y, Xiong Z, Ye B, Du Y, Tian Y, Yin Z, Xu Z, Fan Z. Regulatory innate lymphoid cells control innate intestinal inflammation. Cell. 2017;171(1):201–216.e18. doi: 10.1016/j.cell.2017.07.027.
  15. Ferstl R, Frei R, Barcik W, Schiavi E, Wanke K, Ziegler M, Rodriguez-Perez N, Groeger D, Konieczna P, Zeiter S, Nehrbass D, Lauener R, Akdis CA, O'Mahony L. Histamine receptor 2 modifies iNKT cell activity within the inflamed lung. Allergy. 2017;72(12):1925–1935. doi: 10.1111/all.13227.
  16. Van de Veen W, Stanic B, Wirz OF, Jansen K, Globinska A, Akdis M. Role of regulatory B cells in immune tolerance to allergens and beyond. J Allergy Clin Immunol. 2016;138(3):654–665. doi: 10.1016/j.jaci.2016.07.006.
  17. Layhadi JA, Eguiluz‐Gracia I, Shamji MH. Role of IL‐35 in sublingual allergen immunotherapy. Curr Opin Allergy Clin Immunol. 2019;19(1):12–17. doi: 10.1097/ACI.0000000000000499.
  18. Kucuksezer UC, Ozdemir C, Akdis M, Akdis CA. Precision/personalized medicine in allergic diseases and asthma. Arch Immunol Ther Exp. 2018;66(6):431–442. doi: 10.1007/s00005-018-0526-6.
  19. Ozdemir C, Kucuksezer UC, Akdis M, Akdis CA. Mechanisms of aeroallergen immunotherapy: Subcutaneous immunotherapy and sublingual immunotherapy. Immunol Allergy Clin North Am. 2016;36(1):71–86. doi: 10.1016/j.iac.2015.08.003.
  20. Kucuksezer UC, Ozdemir C, Akdis M, Akdis CA. Mechanisms of immune tolerance to allergens in children. Korean J Pediatr. 2013;56(12):505–513. doi: 10.3345/kjp.2013.56.12.505.
  21. Dhami S, Nurmatov U, Arasi S, Khan T, Asaria M, Zaman H, Agarwal A, Netuveli G, Roberts G, Pfaar O, Muraro A, Ansotegui IJ, Calderon M, Cingi C, Durham S, van Wijk RG, Halken S, Hamelmann E, Hellings P, Jacobsen L, Knol E, Larenas-Linnemann D, Lin S, Maggina P, Mösges R, Oude Elberink H, Pajno G, Panwankar R, Pastorello E, Penagos M, Pitsios C, Rotiroti G, Timmermans F, Tsilochristou O, Varga EM, Schmidt-Weber C, Wilkinson J, Williams A, Worm M, Zhang L, Sheikh A. Allergen immunotherapy for allergic rhinoconjunctivitis: A systematic review and meta-analysis. Allergy. 2017;72(11):1597–1631. doi: 10.1111/all.13201.
  22. Alvaro-Lozano M, Akdis CA, Akdis M, Alviani C, Angier E, Arasi S, Arzt-Gradwohl L, Barber D, Bazire R, Cavkaytar O, Comberiati P, Dramburg S, Durham SR, Eifan AO, Forchert L, Halken S, Kirtland M, Kucuksezer UC, Layhadi JA, Matricardi PM, Muraro A, Ozdemir C, Pajno GB, Pfaar O, Potapova E, Riggioni C, Roberts G, Rodríguez Del Río P, Shamji MH, Sturm GJ, Vazquez-Ortiz M. EAACI allergen immunotherapy user's guide. Pediatr Allergy Immunol. 2020;31(Suppl 25):1–101. doi: 10.1111/pai.13189.
  23. Dhami S, Kakourou A, Asamoah F, Agache I, Lau S, Jutel M, Muraro A, Roberts G, Akdis CA, Bonini M, Cavkaytar O, Flood B, Gajdanowicz P, Izuhara K, Kalayci Ö, Mosges R, Palomares O, Pfaar O, Smolinska S, Sokolowska M, Asaria M, Netuveli G, Zaman H, Akhlaq A, Sheikh A. Allergen immunotherapy for allergic asthma: A systematic review and meta-analysis. Allergy. 2017;72(12):1825–1848. doi: 10.1111/all.13208.
  24. Van de Griendt E‐J, Tuut MK, de Groot H, Brand PLP. Applicability of evidence from previous systematic reviews on immunotherapy in current practice of childhood asthma treatment: a GRADE (Grading of Recommendations Assessment, Development and Evaluation) systematic review. BMJ Open. 2017;7(12):e016326.
  25. Kim JM, Lin SY, Suarez-Cuervo C, Chelladurai Y, Ramanathan M, Segal JB, Erekosima N. Allergen-specific immunotherapy for pediatric asthma and rhinoconjunctivitis: A systematic review. Pediatrics. 2013;131(6):1155–1167. doi: 10.1542/peds.2013-0343.
  26. Normansell R, Kew KM, Bridgman A‐L. Sublingual immunotherapy for asthma. Cochrane Database Syst Rev. 2015(8):CD011293. doi: 10.1002/14651858.CD011293.pub2.
  27. Papadopoulos NG, Čustović A, Cabana MD, Dell SD, Deschildre A, Hedlin G, Hossny E, Le Souëf P, Matricardi PM, Nieto A, Phipatanakul W, Pitrez PM, Pohunek P, Gavornikova M, Jaumont X, Price DB. Pediatric asthma: An unmet need for more effective, focused treatments. Pediatr Allergy Immunol. 2019;30(1):7–16. PMID: 30312503. PMCID: PMC7380053. doi: 10.1111/pai.12990.
  28. Blanco C, Bazire R, Argiz L, Hernández-Peña J. Sublingual allergen immunotherapy for respiratory allergy: A systematic review. Drugs Context. 2018;7:212552. doi: 10.7573/dic.212552.
  29. Kim JM, Lin SY, Suarez-Cuervo C, Chelladurai Y, Ramanathan M, Segal JB, Erekosima N. Allergen-specific immunotherapy for pediatric asthma and rhinoconjunctivitis: a systematic review. Pediatrics. 2013;131(6):1155–1167. doi: 10.1542/peds.2013-0343.
  30. Rice JL, Diette GB, Suarez-Cuervo C, Brigham EP, Lin SY, Ramanathan MJr, Robinson KA, Azar A. Allergen-Specific Immunotherapy in the Treatment of Pediatric Asthma: A systematic review. Pediatrics. 2018;141(5):e20173833. doi: 10.1542/peds.2017-3833.
  31. Halken S, Larenas-Linnemann D, Roberts G, Calderón MA, Angier E, Pfaar O, Ryan D, Agache I, Ansotegui IJ, Arasi S, Du Toit G, Fernandez-Rivas M, Geerth van Wijk R, Jutel M, Kleine-Tebbe J, Lau S, Matricardi PM, Pajno GB, Papadopoulos NG, Penagos M, Santos AF, Sturm GJ, Timmermans F, van Ree R, Varga EM, Wahn U, Kristiansen M, Dhami S, Sheikh A, Muraro A. EAACI guidelines on allergen immunotherapy: Prevention of allergy. Pediatr Allergy Immunol. 2017;28(8):728–745. doi: 10.1111/pai.12807.
  32. Grazax Asthma Prevention (GAP) Study. http://clinicaltrials.gov/ct2/show/NCT01061203?term=Grazax+Asthma+Prevention+%28GAP%29+Study&rank=1 (access date: 12.05.2022).
  33. Di Lorenzo G, Leto-Barone MS, La Piana S, Plaia A, Di Bona D. The effect of allergen immunotherapy in the onset of new sensitizations: a meta-analysis. Int Forum Allergy Rhinol. 2017;7(7):660–669. doi: 10.1002/alr.21946.
  34. Di Bona D, Plaia A, Leto-Barone MS, La Piana S, Macchia L, Di Lorenzo G. Efficacy of allergen immunotherapy in reducing the likelihood of developing new allergen sensitizations: A systematic review. Allergy. 2017;72(5):691–704. doi: 10.1111/all.13104.
  35. Roberts G, Pfaar O, Akdis CA, Ansotegui IJ, Durham SR, Gerth van Wijk R, Halken S, Larenas-Linnemann D, Pawankar R, Pitsios C, Sheikh A, Worm M, Arasi S, Calderon MA, Cingi C, Dhami S, Fauquert JL, Hamelmann E, Hellings P, Jacobsen L, Knol EF, Lin SY, Maggina P, Mösges R, Oude Elberink JNG, Pajno GB, Pastorello EA, Penagos M, Rotiroti G, Schmidt-Weber CB, Timmermans F, Tsilochristou O, Varga EM, Wilkinson JN, Williams A, Zhang L, Agache I, Angier E, Fernandez-Rivas M, Jutel M, Lau S, van Ree R, Ryan D, Sturm GJ, Muraro A. EAACI Guidelines on allergen immunotherapy: Allergic rhinoconjunctivitis. Allergy. 2018;73(4):765–798. doi: 10.1111/all.13317.
  36. Pajno GB, Bernardini R, Peroni D, Arasi S, Martelli A, Landi M, Passalacqua G, Muraro A, La Grutta S, Fiocchi A, Indinnimeo L, Caffarelli C, Calamelli E, Comberiati P, Duse M; Allergen-specific Immunotherapy panel of the Italian Society of Pediatric Allergy and Immunology (SIAIP). Clinical practice recommendations for allergen-specific immunotherapy in children: The Italian consensus report. Ital J Pediatr. 2017;43(1):13. doi: 10.1186/s13052-016-0315-y.
  37. Canonica GW, Cox L, Pawankar R, Baena-Cagnani CE, Blaiss M, Bonini S, Bousquet J, Calderón M, Compalati E, Durham SR, van Wijk RG, Larenas-Linnemann D, Nelson H, Passalacqua G, Pfaar O, Rosário N, Ryan D, Rosenwasser L, Schmid-Grendelmeier P, Senna G, Valovirta E, Van Bever H, Vichyanond P, Wahn U, Yusuf O. Sublingual immunotherapy: World Allergy Organization position paper 2013 update. World Allergy Organ J. 2014;7(1):6. doi: 10.1186/1939-4551-7-6.
  38. Burks AW, Calderon MA, Casale T, Cox L, Demoly P, Jutel M, Nelson H, Akdis CA. Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immuno-logy/PRACTALL consensus report. J Allergy Clin Immunol. 2013;131(5):1288–1296.e3. doi: 10.1016/j.jaci.2013.01.049.
  39. Bousquet J, Schünemann HJ, Togias A, Bachert C, Erhola M, Hellings PW, Klimek L, Pfaar O, Wallace D, Ansotegui I, Agache I, Bedbrook A, Bergmann KC, Bewick M, Bonniaud P, Bosnic-Anticevich S, Bossé I, Bouchard J, Boulet LP, Brozek J, Brusselle G, Calderon MA, Canonica WG, Caraballo L, Cardona V, Casale T, Cecchi L, Chu DK, Costa EM, Cruz AA, Czarlewski W, D'Amato G, Devillier P, Dykewicz M, Ebisawa M, Fauquert JL, Fokkens WJ, Fonseca JA, Fontaine JF, Gemicioglu B, van Wijk RG, Haahtela T, Halken S, Ierodiakonou D, Iinuma T, Ivancevich JC, Jutel M, Kaidashev I, Khaitov M, Kalayci O, Kleine Tebbe J, Kowalski ML, Kuna P, Kvedariene V, La Grutta S, Larenas-Linnemann D, Lau S, Laune D, Le L, Lieberman P, Lodrup Carlsen KC, Lourenço O, Marien G, Carreiro-Martins P, Melén E, Menditto E, Neffen H, Mercier G, Mosgues R, Mullol J, Muraro A, Namazova L, Novellino E, O'Hehir R, Okamoto Y, Ohta K, Park HS, Panzner P, Passalacqua G, Pham-Thi N, Price D, Roberts G, Roche N, Rolland C, Rosario N, Ryan D, Samolinski B, Sanchez-Borges M, Scadding GK, Shamji MH, Sheikh A, Bom AT, Toppila-Salmi S, Tsiligianni I, Valentin-Rostan M, Valiulis A, Valovirta E, Ventura MT, Walker S, Waserman S, Yorgancioglu A, Zuberbier T; Allergic Rhinitis and Its Impact on Asthma Working Group. Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Re-commendations Assessment, Development and Evaluation (GRADE) and real-world evidence. J Allergy Clin Immunol. 2020;145(1):70–80.e3. doi: 10.1016/j.jaci.2019.06.049.
  40. Halken S, Larenas-Linnemann D, Roberts G, Calderón MA, Angier E, Pfaar O, Ryan D, Agache I, Ansotegui IJ, Arasi S, Du Toit G, Fernandez-Rivas M, Geerth van Wijk R, Jutel M, Kleine-Tebbe J, Lau S, Matricardi PM, Pajno GB, Papadopoulos NG, Penagos M, Santos AF, Sturm GJ, Timmermans F, van Ree R, Varga EM, Wahn U, Kristiansen M, Dhami S, Sheikh A, Muraro A. EAACI guidelines on allergen immunotherapy: Prevention of allergy. Pediatr Allergy Immunol. 2017;28(8):728–745. doi: 10.1111/pai.12807.
  41. Kristiansen M, Dhami S, Netuveli G, Halken S, Muraro A, Roberts G, Larenas-Linnemann D, Calderón MA, Penagos M, Du Toit G, Ansotegui IJ, Kleine-Tebbe J, Lau S, Matricardi PM, Pajno G, Papadopoulos NG, Pfaar O, Ryan D, Santos AF, Timmermanns F, Wahn U, Sheikh A. Allergen immunotherapy for the prevention of allergy: A systematic review and meta-analysis. Pediatr Allergy Immunol. 2017;28(1):18–29. doi: 10.1111/pai.12661.
  42. Pitsios C, Demoly P, Bilò MB, Gerth van Wijk R, Pfaar O, Sturm GJ, Rodriguez del Rio P, Tsoumani M, Gawlik R, Paraskevopoulos G, Ruëff F, Valovirta E, Papadopoulos NG, Calderón MA. Clinical contraindications to allergen immunotherapy: an EAACI position paper. Allergy. 2015;70(8):897–909. doi: 10.1111/all.12638.
  43. Canonica GW, Ansotegui IJ, Pawankar R, Schmid-Grendelmeier P, van Hage M, Baena-Cagnani CE, Melioli G, Nunes C, Passalacqua G, Rosenwasser L, Sampson H, Sastre J, Bousquet J, Zuberbier T, WAO-ARIA-GA2LEN Task Force: Allen K, Asero R, Bohle B, Cox L, de Blay F, Ebisawa M, Maximiliano-Gomez R, Gonzalez-Diaz S, Haahtela T, Holgate S, Jakob T, Larche M, Maria Matricardi P, Oppenheimer J, Poulsen LK, Renz HE, Rosario N, Rothenberg M, Sanchez-Borges M, Scala E, Valenta R. A WAO–ARIA–GA2LEN consensus document on molecular-based allergy diagnostics. World Allergy Organ J. 2013;6:17. doi: 10.1186/1939-4551-6-17.
  44. Steering Committee Authors; Review Panel Members. A WAO — ARIA — GA2LEN consensus document on molecular-based allergy diagnosis (PAMD@): Update 2020. World Allergy Organ J. 2020;13(2):100091. doi: 10.1016/j.waojou.2019.100091.
  45. Matricardi PM. Molecular profile clustering of IgE responses and potential implications for specific immunotherapy. Curr Opin Allergy Clin Immunol. 2013;13:438–445. doi: 10.1097/ACI.0b013e3283630ca5.
  46. Sastre J, Landivar ME, Ruiz-García M, Andregnette-Rosigno MV, Mahillo I. How molecular diagnosis can change allergen-specific immunotherapy prescription in a complex pollen area. Allergy. 2012;67:709–711. doi: 10.1111/j.1398-9995.2012.02808.x.
  47. Passalacqua G, Melioli G, Bonifazi F, Bonini S, Maggi E, Senna G, Triggiani M, Nettis E, Rossi RE, Vacca A, Canonica GW, Italian ISAC Study Group. The additional values of microarray allergen assay in the management of polysensitized patients with respiratory allergy. Allergy. 2013;68:1029–1033. doi: 10.1111/all.12194.
  48. Zimmer J, Vieths S, Kaul S. Standardization and regulation of allergen products in the European Union. Curr Allergy Asthma Rep. 2016;16(3):21. doi: 10.1007/11882-016-0599-4.
  49. Bonertz A, Mahler V, Vieths S. Manufacturing and quality assessment of allergenic extracts for immunotherapy: State of the art. Curr Opin Allergy Clin Immunol. 2019;19(6):640–645. doi: 10.1097/ACI.0000000000000579.
  50. Pfaar O, van Twuijver E, Boot JD, Opstelten DJ, Klimek L, van Ree R, Diamant Z, Kuna P, Panzner P. A randomized DBPC trial to determine the optimal effective and safe dose of a SLIT-birch pollen extract for the treatment of allergic rhinitis: results of a phase II study. Allergy. 2016;71:99–107. doi: 10.1111/all.12760.
  51. Pajno GB, Bernardini R, Peroni D, Arasi S, Martelli A, Landi M, Passalacqua G, Muraro A, La Grutta S, Fiocchi A, Indinnimeo L, Caffarelli C, Calamelli E, Comberiati P, Duse M; Allergen-specific Immunotherapy panel of the Italian Society of Pediatric Allergy and Immunology (SIAIP). Clinical practice recommendations for allergen-specific immunotherapy in children: The Italian consensus report. Ital J Pediatr. 2017;43(1):13. doi: 10.1186/s13052-016-0315-y.
  52. Duman Senol H, Topyildiz E, Ekici B, Gulen F, Demir E. Effectiveness and adverse reactions to subcutaneous immunotherapy in children with allergic rhinitis/asthma. Int J Pediatr Otorhinolaryngol. 2022;162:111292. doi: 10.1016/j.ijporl.2022.111292.
  53. Jutel M, Bartkowiak-Emeryk M, Bręborowicz A, Cichocka-Jarosz E, Emeryk A, Gawlik R, Gonerko P, Rogala B, Nowak-Węgrzyn A, Samoliński B; IT Section, PTA. Sublingual immunotherapy (SLIT) — indications, mechanism, and efficacy: Position paper prepared by the Section of Immunotherapy, Polish Society of Allergy. Ann Agric Environ Med. 2016;23(1):44–53. doi: 10.5604/12321966.1196851.
  54. Agache I, Lau S, Akdis CA, Smolinska S, Bonini M, Cavkaytar O, Flood B, Gajdanowicz P, Izuhara K, Kalayci O, Mosges R, Palomares O, Papadopoulos NG, Sokolowska M, Angier E, Fernandez-Rivas M, Pajno G, Pfaar O, Roberts GC, Ryan D, Sturm GJ, van Ree R, Varga EM, van Wijk RG, Yepes-Nuñez JJ, Jutel M. EAACI guidelines on allergen immunotherapy: House dust mite-driven allergic asthma. Allergy. 2019;74(5):855–873. doi: 10.1111/all.13749.
  55. Wahn U, Bachert C, Heinrich J, Richter H, Zielen S. Real-world benefits of allergen immunotherapy for birch pollen-associated allergic rhinitis and asthma. Allergy. 2019;74(3):594–604. doi: 10.1111/all.13598.
  56. Kiel MA, Roder E, Gerth van Wijk R, Al MJ, Hop WC, Rutten‐van Molken MP. Real‐life compliance and persistence among users of subcutaneous and sublingual allergen immunotherapy. J Allergy Clin Immunol. 2013;132(2):353–360. doi: 10.1016/j.jaci.2013.03.013.
  57. Durham SR, Emminger W, Kapp A, de Monchy JG, Rak S, Scadding GK, Wurtzen PA, Andersen JS, Tholstrup B, Riis B, Dahl R. SQ-standardized sublingual grass immunotherapy: confirmation of disease modification 2 years after 3 years of treatment in a randomized trial. J Allergy Clin Immunol. 2012;129(3):717–725.e5. doi: 10.1016/j.jaci.2011.12.973.
  58. Didier A, Malling HJ, Worm M, Horak F, Sussman GL. Prolonged efficacy of the 300IR 5‐grass pollen tablet up to 2 years after treatment cessation, as measured by a recommended daily combined score. Clin Transl Allergy. 2015;5:12.
  59. Scadding GW, Calderon MA, Shamji MH, Eifan AO, Penagos M, Dumitru F, Sever ML, Bahnson HT, Lawson K, Harris KM, Plough AG, Panza JL, Qin T, Lim N, Tchao NK, Togias A, Durham SR; Immune Tolerance Network GRASS Study Team. Effect of 2 years of treatment with sublingual grass pollen immunotherapy on nasal response to allergen challenge at 3 years among patients with moderate to severe seasonal allergic rhinitis: The GRASS randomized clinical trial. JAMA. 2017;317(6):615–625. doi: 10.1001/jama.2016.21040.
  60. Bergmann KC, Demoly P, Worm M, Fokkens WJ, Carrillo T, Tabar AI, Nguyen H, Montagut A, Zeldin RK. Efficacy and safety of sublingual tablets of house dust mite allergen extracts in adults with allergic rhinitis. J Allergy Clin Immunol. 2014;133(6):1608–14.e6. doi: 10.1016/j.jaci.2013.11.012.
  61. Mosbech H, Canonica GW, Backer V, de Blay F, Klimek L, Broge L, Ljørring C. SQ house dust mite sublingually administered immunotherapy tablet (ALK) improves allergic rhinitis in patients with house dust mite allergic asthma and rhinitis symptoms. Ann Allergy Asthma Immunol. 2015;114(2):134–140. doi: 10.1016/j.anai.2014.11.015.
  62. Demoly P, Emminger W, Rehm D, Backer V, Tommerup L, Kleine‐Tebbe J. Effective treatment of house dust mite‐induced allergic rhinitis with 2 doses of the SQ HDM SLIT‐tablet: Results from a randomized, double‐blind, placebo‐controlled phase III trial. J Allergy Clin Immunol. 2016;137(2):444–451.
  63. Yukselen A, Kendirli SG, Yilmaz M, Altintas DU, Karakoc GB. Effect of one-year subcutaneous and sublingual immunotherapy on clinical and laboratory para-meters in children with rhinitis and asthma: a randomized, placebo-controlled, double-blind, double-dummy study. Int Arch Allergy Immunol. 2012;157(3):288–298. doi: 10.1159/000327566.
  64. Smolkin YuS, Masalskiy SS, Cheburkin AA, Andronova YeV, Kuropatnikova YeA, Larkova IA, Lepeshkova TS, Lyan NA, Maksimova AV, Migacheva NB, Stezhkina YeV, Trusova OV, Khakimova RF, Churyukina EV. Allergen-spetsificheskaya immunoterapiya u detey (na pravakh rukovodstva). Soglasitelnyy dokument Assotsiatsii detskikh allergologov i immunologov Rossii. (Allergen-specific immunotherapy in children (as a guideline). Conciliation document of the Association of Children's Allergists and Immunologists of Russia.) Moskva: ADAIR; Podolsk: OAO “Podolskaya fabrika ofsetnoy pechati”; 2021. 198 р. (In Russ.)
  65. Arroabarren E, Tabar AI, Echechipía S, Cambra K, García BE, Alvarez-Puebla MJ. Optimal duration of allergen immunotherapy in children with dust mite respiratory allergy. Pediatr Allergy Immunol. 2015;26:34–41. doi: 10.1111/pai.12296.
  66. Pajno GB, Caminiti L, Passalacqua G. Changing the route of immunotherapy administration: An 18-year survey in pediatric patients with allergic rhinitis and asthma. Allergy Asthma Proc. 2013;34:523–526. doi: 10.2500/aap.2013.34.3696.
  67. Pajno GB, Caminiti L, Crisafulli G, Barberi S, Landi M, Aversa T. Adherence to sublingual immunotherapy in preschool children. Pediatr Allergy Immunol. 2012;23:688–689. doi: 10.1111/j.1399-3038.2012.01317.x.
  68. Riccio AM, De Ferrari L, Chiappori A, Ledda S, Passalacqua G, Melioli G, Canonica GW. Molecular diagnosis and precision medicine in allergy management. Clin Chem Lab Med. 2016;54(11):1705–1714. doi: 10.1515/cclm-2016-0007.
  69. Calderon MA, Gerth van Wijk R, Eichler I, Matricardi PM, Varga EM, Kopp MV, Eng P, Niggemann B, Nieto A, Valovirta E, Eigenmann PA, Pajno G, Bufe A, Halken S, Beyer K, Wahn U; European Academy of Allergy and Clinical Immunology. Perspectives on allergen-specific immunotherapy in childhood: An EAACI position statement. Pediatr Allergy Immunol. 2012;23(4):300–306. doi: 10.1111/j.1399-3038.2012.01313.x.
  70. Passalacqua G, Baena-Cagnani CE, Bousquet J, Canonica GW, Casale TB, Cox L, Durham SR, Larenas-Linnemann D, Ledford D, Pawankar R, Potter P, Rosario N, Wallace D, Lockey RF. Grading local side effects of sublingual immunotherapy for respiratory allergy: Speaking the same language. J Allergy Clin Immunol. 2013;132(1):93–98. doi: 10.1016/j.jaci.2013.03.039.
  71. Passalacqua G, Nowak-Węgrzyn A, Canonica GW. Local side effects of sublingual and oral immunotherapy. J Allergy Clin Immunol Pract. 2017;5(1):13–21. doi: 10.1016/j.jaip.2016.06.020.
  72. Arasi S, Passalacqua G, Caminiti L, Crisafulli G, Fiamingo C, Pajno GB. Efficacy and safety of sublingual immunotherapy in children. Expert Rev Clin Immunol. 2016;12(1):49–56. doi: 10.1586/1744666X.2016.1102058.
  73. Rodríguez Del Río P, Vidal C, Just J, Tabar AI, Sanchez-Machin I, Eberle P, Borja J, Bubel P, Pfaar O, Demoly P, Calderón MA. The European Survey on Adverse Systemic Reactions in Allergen Immunotherapy (EASSI): A paediatric assessment. Pediatr Allergy Immunol. 2017;28(1):60–70. doi: 10.1111/pai.12660.
  74. Calderón MA, Vidal C, Rodríguez Del Río P, Just J, Pfaar O, Tabar AI, Sánchez-Machín I, Bubel P, Borja J, Eberle P, Reiber R, Bouvier M, Lepelliez A, Klimek L, Demoly P; EASSI Doctors' Group. European Survey on Adverse Systemic Reactions in Allergen Immunotherapy (EASSI): A real-life clinical assessment. Allergy. 2017;72(3):462–472. doi: 10.1111/all.13066.
  75. Moingeon P. Update on immune mechanisms associated with sublingual immunotherapy: Practical implications for the clinician. J Allergy Clin Immunol Pract. 2013;1(3):228–241. doi: 10.1016/j.jaip.2013.03.013.
  76. Lawrence MG, Steinke JW, Borish L. Basic science for the clinician: Mechanisms of sublingual and subcutaneous immunotherapy. Ann Allergy Asthma Immunol. 2016;117(2):138–142. doi: 10.1016/j.anai.2016.06.027.
  77. Schulten V, Tripple V, Aasbjerg K, Backer V, Lund G, Würtzen PA, Sette A, Peters B. Distinct modulation of allergic T cell responses by subcutaneous vs. sublingual allergen-specific immunotherapy. Clin Exp Allergy. 2016;46(3):439–448. doi: 10.1111/cea.12653.
  78. Passalacqua G, Baena-Cagnani CE, Bousquet J, Canonica GW, Casale TB, Cox L, Durham SR, Larenas-Linnemann D, Ledford D, Pawankar R, Potter P, Rosario N, Wallace D, Lockey RF. Grading local side effects of sublingual immunotherapy for respiratory allergy: Speaking the same language. J Allergy Clin Immunol. 2013;132(1):93–98. doi: 10.1016/j.jaci.2013.03.039.
  79. Passalacqua G, Nowak-Węgrzyn A, Canonica GW. Local side effects of sublingual and oral immunotherapy. J Allergy Clin Immunol Pract. 2017;5(1):13–21. doi: 10.1016/j.jaip.2016.06.020.

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