Evaluation of the impact of specific preventive measures on the incidence of tick-borne viral encephalitis in the Altai Krai in 2000-2017
- Authors: Saldan IP1, Timonin AV1, Shirokostup SV1, Luk’yanenko NV1, Balandovich BA1
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Affiliations:
- Altai State Medical University
- Issue: Vol 100, No 3 (2019)
- Pages: 476-481
- Section: Social hygiene and healthcare management
- URL: https://journals.rcsi.science/kazanmedj/article/view/13346
- DOI: https://doi.org/10.17816/KMJ2019-476
- ID: 13346
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Abstract
Aim. Analysis of the effectiveness of specific preventive measures against tick-borne viral encephalitis among the urban and rural population of the Altai Krai of different age groups in 2000-2017.
Methods. The paper presents the results of a long-term epidemiological analysis of the incidence among urban and rural population of the Altai Krai of tick-borne viral encephalitis in 2000-2017, the calculation of absolute and relative indicators, long-standing dynamics of the incidence of tick-borne viral encephalitis in RF ad Altai Krai was evaluzted as well as summarized parameter of vaccination and revaccination. Statistical data processing was carried out in the program Statistica 12.0.
Results. The study revealed an inverse moderate correlation between the factor of the volume of emergency prophylaxis and the incidence of tick-borne viral encephalitis among the population of the Altai Krai (r=-0.51; p <0.001), between these phenomena in the cohort of adult population of the region (r=-0.50; p <0.001), in the cohort of children in the region (r=-0.52; p <0.001), in the cohort of urban residents (r=-0.54; p <0.001), in the cohort of rural residents (r=-0,45; p <0.001). The causes of differences in the incidence of tick-borne viral encephalitis among the urban and rural population of the Altai Krai were identified, the degree of relation between the average long-term incidence rates and its determining factors were determined, recommendations were developed to optimize the system of preventive measures of tick-borne encephalitis in the region.
Conclusion. The absence of a negative correlation in the various cohorts of the population between the incidence and vaccination levels indicates a lack of effectiveness of vaccination against tick-borne viral encephalitis in the region; at the same time, the inverse moderate correlation revealed between the incidence of tick-borne viral encephalitis and the indicators of emergency immunoprophylaxis indicates a sufficient degree of effectiveness of this specific preventive measure in the Altai Krai.
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##article.viewOnOriginalSite##About the authors
I P Saldan
Altai State Medical University
Email: shirokostup@yandex.ru
Barnaul, Russia
A V Timonin
Altai State Medical University
Email: shirokostup@yandex.ru
Barnaul, Russia
S V Shirokostup
Altai State Medical University
Author for correspondence.
Email: shirokostup@yandex.ru
Barnaul, Russia
N V Luk’yanenko
Altai State Medical University
Email: shirokostup@yandex.ru
Barnaul, Russia
B A Balandovich
Altai State Medical University
Email: shirokostup@yandex.ru
Barnaul, Russia
References
- Kozlova I.V., Tkachev S.E., Savinova Yu.S. et al. Ecology features of the European subtype tick-borne encephalitis virus in Siberia. Epidemiologiya i vaktsinoprofilaktika. 2017; 16 (1): 22–25. (In Russ.)
- Bobrovskiy E.A., Shirokostup S.V., Luk’yanenko N.V., Saf’yanova T.V. Unified regional vaccine management system. Zhurnal infektologii. 2016; (S2): 25–26. (In Russ.)
- Shchuchinova L.D., Schuchinov L.V., Zlobin V.I. Analysis of factors affecting the effectiveness of vaccination against tick-borne encephalitis. Epidemiologiya and vaktsinoprofilaktika. 2016; 15 (2): 72–76. (In Russ.)
- McAuley A.J., Sawatsky B., Ksiazek T. et al. Cross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection. NPJ vaccines. 2017; 1 (2): 5. doi: 10.1038/s41541-017-0009-5.
- Lotric-Furlan S., Bogovic P., Avsic-Zupanc T. et al. Tick-borne encephalitis in patients vaccinated against this disease. J. Intern. Med. 2017; 2 (282): 142–155. doi: 10.1111/joim.12625.
- Nikitin A.Y., Andaev E.I., Noskov A.K. et al. Features of the epidemiological situation on tick-borne viral encephalitis in the Russian Federation in 2017 and its development forecast for 2018. Problemy osobo opasnykh infektsiy. 2018; (1): 44–49. (In Russ.)
- Shirokostup S.V. Epidemiological features of tick-borne infections in the Altai Territory in 2010–2015. Infektologiya. 2015; 1 (1): 3–5. (In Russ.)
- Dela Fuente J., Contreras M., Estrada-Pena A. et al. Targeting a global health problem: vaccine design and challenges for the control of tick-borne diseases. Vaccine. 2017; 38 (38): 5089–5094. doi: 10.1016/j.vaccine.2017.07.097.
- Elsterova J., Palus M., Sirmarova J. et al. Tick-borne encephalitis virus neutralization by high dose intravenous immunoglobulin. Ticks and tick-borne diseases. 2017; 2 (8): 253–258. doi: 10.1016/j.ttbdis.2016.11.007.
- Kollaritsch H., Heininger U. Tick-borne encephalitis vaccines. Pediatric vaccines and vaccinations. Springer, Cham. 2017; 264 p. doi: 10.1007/978-3-319-59952-6_16.