Study of the effect of ammonium iron citrate on the virulence of nontuberculous mycobacteria

Abstract

The method of the determination of the virulence of nontuberculous mycobacteria by the injection of ferric iron salts to white mice is developed, the comparative analysis of the I sensitivity of this method and estimation of the virulence of mycobacteria by sensitization of white mice by pertussoid monovalent vaccine is performed. The investigations are carried out on 270 not pedigree white mice with 6 species of nontuberculous mycobacteria. It is established that the injection of ammonium iron citrate increases the virulence of the all nontuberculous mycobacteria strains studied except for M. phlei. The method given proved to be more sensitive than the method with pertussoid vaccine.

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