Possibilities of drug regulation of inflammation

For many years and to this day, the main drugs used to regulate inflammation are steroidal and nonsteroidal anti-inflammatory drugs. Glucocorticosteroids (GCS) are characterized by a powerful anti-inflammatory effect, which, however, is accompanied by a variety of side effects with systemic action, which limits their wide use. Non-steroidal anti-inflammatory drugs (NSAIDs, non-steroidal antiphlogistics) belong to one of the most frequently prescribed medications in world medical practice. Studies by Vein [66], which showed that the mechanism of action of acetylsalicylic acid and other NSAIDs is based on the inhibition of prostaglandin biosynthesis - local modulators of inflammation, were the beginning of modern inflammation pharmacology.