To the issue of the use of sodium-lithium countertransport rate in red cell membrane as a prognostic marker of artherial hypertension mordbidity and mortality: an experience of 25-year follow up cohort study
- Authors: Makarov MA1, Oslopov VN1, Ganeeva KI2
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Affiliations:
- Kazan State Medical University
- City hospital No 11
- Issue: Vol 99, No 5 (2018)
- Pages: 839-846
- Section: Clinical experiences
- URL: https://journals.rcsi.science/kazanmedj/article/view/10312
- DOI: https://doi.org/10.17816/KMJ2018-839
- ID: 10312
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Abstract
Aim. The article discusses the results of a long-term cohort study devoted to the search for the possible relationship of arterial hypertension morbidity and mortality with the rate of sodium-lithium countertransport (Na+-Li+-СT) in red cell membrane which is a marker of the structural and functional state of the cell membrane.
Methods. The study of the functional state of cell membranes by determining the maximal rate of Na+-Li+-CT in red cell membrane with quintiles analysis of the rate of Na+-Li+-CT. Screening clinical examination, including registration of blood pressure (BP), ECG study, the study of eyeground vessels, one- and two-dimensional echocardiography (EchoCG), the study of the lipid spectrum of the blood. Analysis of medical records.
Results. Based on the results of long-term follow up of the aging cohort total mortality is not associated with Na+-Li+-СT rate in red cell membrane. At the average age of 50 bimodality is detected in the development of new cases of primary arterial hypertension associated with the values of Na+-Li+-СT rate of the 1st quartile (36-206 micromoles of Li per liter of cells per hour) and 3d quartile (276-347 micromoles of Li per liter of cells per hour). At the average age of cohort of 55.6±6.7 years the distribution of patients with arterial hypertension by quartiles of Na+-Li+-СT rate becomes almost identical with the statistically non-significant prevalence of 4th quartile of Na+-Li+-СT rate.
Conclusion. The expected correlation between mortality among persons with hypertension and membrane disorders determined by the high rate of Na+-Li+-СT was not revealed. However, the tendency to the predominance of mortality at high Na+-Li+-СT rate suggests that with a much larger sample size a significant relationship may be confirmed. The necessity of studying the relationship between mortality from arterial hypertension and high rate of Na+-Li+-СT in female cohorts remains actual. Increasing difference of mortality rate among patients with and without arterial hypertension with high rate of Na+-Li+-СT can indicate the relationship between mortality from arterial hypertension and membrane disorders.
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##article.viewOnOriginalSite##About the authors
M A Makarov
Kazan State Medical University
Author for correspondence.
Email: maks.vfrfhjd2011@yandex.ru
Kazan, Russia
V N Oslopov
Kazan State Medical University
Email: maks.vfrfhjd2011@yandex.ru
Kazan, Russia
K I Ganeeva
City hospital No 11
Email: maks.vfrfhjd2011@yandex.ru
Kazan, Russia
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