Dynamics and prognostic value of morphological changes of regional lymph nodes to a cancerous tumor

Increasing morbidity and high mortality of patients with cancer of different organs dictate the necessity to search for effective methods of early diagnosis and treatment of malignant neoplasms as well as to study the factors determining the course of the disease and its prognosis. The successful solution of these tasks is impossible without thorough investigation of the functional morphology of the lymph nodes adjacent to the tumor, which play the role of the first barrier in the path of cancer metastasis. Finding out the role of lymph nodes in tumor metastasis is one of the major issues of modern oncology, because presence of metastases in regional lymph nodes worsens prognosis considerably, decreasing 5-year survival period.