On the effect of synthomycin on the cardiovascular system in typhoid fever

The greatest modern achievement in typhoid fever therapy was the use of synthomycin and levomycetin. In this way, as shown by V. N. Orekhovich, G., P. Rudnev, A. F. Bilibin and many others, it is possible to achieve rapid improvement of the general state of patients, the relief of fever and reduction of the period of the disease. But the question of the cardiovascular system condition, the frequency of brucellosis myocarditis and subsequent changes of cardiovascular activity during synthomycin treatment has not been specifically studied. We made an attempt to clarify the effect of synthomycin on the cardiovascular system during typhoid fever. For this purpose we compared changes of the cardiovascular system in 50 patients with typhoid fever treated by usual methods and in 54 patients who received, along with symptomatic therapy, treatment with synthomycin.