On the dynamics of 17-ketosteroids in urine during treatment of rheumatism with antirheumatic agents

To date, there is no consensus on the etiology of rheumatism. The most common is the streptococcal theory of rheumatism - about ß-hemolytic streptococcus type A (V. T. Talalaev, N. D. Strazhesko, A. I. Nesterov, Aschoff, Gräff, Fahr and others) and the streptococcal theory (G. D. Zaleski, O. P. Peterson, Swift and others). The authors' point of view on the pathogenesis of rheumatism is relatively consistent. All authors recognize that in the pathogenesis of rheumatism the leading role is played by the disturbance of two systems: hyaluronidase-hyaluronic acid system and disturbance of hormonal function of pituitary-adrenal system, namely, inhibition of ACTH synthesis, which is a stimulator of adrenal cortex hormones.