NAT2 and CYP1B1 genetic polymorphisms in patients with genital endometriosis depending on tolerability of melatonin

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BACKGROUND: Genital endometriosis is one of the most pressing problems of modern gynecology. Melatonin is a promising drug with a potentially curative effect on endometriosis.

AIM: The aim of this study was to conduct a comparative analysis of the genetic polymorphism of some genes encoding enzymes involved in melatonin metabolism.

MATERIALS AND METHODS: The genetic polymorphism in the NAT2 and CYP1B1 genes encoding enzymes involved in melatonin metabolism in patients with different tolerance to this drug was analyzed by PCR-RFLP analysis.

RESULTS: In patients with genital endometriosis, the presence of a wild-type allele (N) of the NAT2 gene was associated with poor tolerance of melatonin. The NAT2 (N / N) rapid acetylator phenotype combined with the low catalytic activity of CYP1B1 (C / C) occurred more frequently in endometriosis patients having poor melatonin tolerability compared to the group of patients who tolerated the therapy well.

CONCLUSIONS: For patients with genital endometriosis with the wild-type (N) allele of the NAT2 gene, melatonin administration is inappropriate due to numerous side effects during the drug use.

作者简介

Tatyana Ivashchenko

Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

Email: tivashchenko2011@mail.ru
ORCID iD: 0000-0002-8549-6505
Scopus 作者 ID: 7004724202

Dr. Sci. (Biol.), Professor,  Department of Molecular Medicine

俄罗斯联邦, 3 Mendeleevskaya Line, Saint Petersburg, 199034

Maria Yarmolinskaya

Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott; North-Western State Medical University named after I.I. Mechnikov

Email: m.yarmolinskaya@gmail.com
ORCID iD: 0000-0002-6551-4147
SPIN 代码: 3686-3605
Scopus 作者 ID: 7801562649
Researcher ID: P-2183-2014

MD, Dr. Sci. (Med.), Professor, Professor of the Russian Academy of Sciences

俄罗斯联邦, 3 Mendeleevskaya Line, Saint Petersburg, 199034; 41 Kirochnaya Str., Saint Petersburg, 191015

Saimat Tkhazaplizheva

Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

编辑信件的主要联系方式.
Email: saim86@yandex.ru

MD, Graduate student in the Department of endocrinology of reproduction

俄罗斯联邦, 3 Mendeleevskaya Line, Saint Petersburg, 199034

参考

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2. Fig. 1. Frequency distribution of NAT2 genotypes depending on melatonin tolerance

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版权所有 © Ivashchenko T., Yarmolinskaya M., Tkhazaplizheva S., 2021



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