Email this article NAT2 and CYP1B1 genetic polymorphisms in patients with genital endometriosis depending on tolerability of melatonin
- Authors: Ivashchenko T.E.1, Yarmolinskaya M.I.1,2, Tkhazaplizheva S.S.1
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Affiliations:
- Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
- North-Western State Medical University named after I.I. Mechnikov
- Issue: Vol 70, No 4 (2021)
- Pages: 35-42
- Section: Original Research
- URL: https://journals.rcsi.science/jowd/article/view/51149
- DOI: https://doi.org/10.17816/JOWD51149
- ID: 51149
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Abstract
BACKGROUND: Genital endometriosis is one of the most pressing problems of modern gynecology. Melatonin is a promising drug with a potentially curative effect on endometriosis.
AIM: The aim of this study was to conduct a comparative analysis of the genetic polymorphism of some genes encoding enzymes involved in melatonin metabolism.
MATERIALS AND METHODS: The genetic polymorphism in the NAT2 and CYP1B1 genes encoding enzymes involved in melatonin metabolism in patients with different tolerance to this drug was analyzed by PCR-RFLP analysis.
RESULTS: In patients with genital endometriosis, the presence of a wild-type allele (N) of the NAT2 gene was associated with poor tolerance of melatonin. The NAT2 (N / N) rapid acetylator phenotype combined with the low catalytic activity of CYP1B1 (C / C) occurred more frequently in endometriosis patients having poor melatonin tolerability compared to the group of patients who tolerated the therapy well.
CONCLUSIONS: For patients with genital endometriosis with the wild-type (N) allele of the NAT2 gene, melatonin administration is inappropriate due to numerous side effects during the drug use.
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##article.viewOnOriginalSite##About the authors
Tatyana E. Ivashchenko
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: tivashchenko2011@mail.ru
ORCID iD: 0000-0002-8549-6505
Scopus Author ID: 7004724202
Dr. Sci. (Biol.), Professor, Department of Molecular Medicine
Russian Federation, 3 Mendeleevskaya Line, Saint Petersburg, 199034Maria I. Yarmolinskaya
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott; North-Western State Medical University named after I.I. Mechnikov
Email: m.yarmolinskaya@gmail.com
ORCID iD: 0000-0002-6551-4147
SPIN-code: 3686-3605
Scopus Author ID: 7801562649
ResearcherId: P-2183-2014
MD, Dr. Sci. (Med.), Professor, Professor of the Russian Academy of Sciences
Russian Federation, 3 Mendeleevskaya Line, Saint Petersburg, 199034; 41 Kirochnaya Str., Saint Petersburg, 191015Saimat S. Tkhazaplizheva
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Author for correspondence.
Email: saim86@yandex.ru
MD, Graduate student in the Department of endocrinology of reproduction
Russian Federation, 3 Mendeleevskaya Line, Saint Petersburg, 199034References
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