电邮这篇文章 Efficiency of gonadotropin-releasing hormone analogue in endometriosis therapy
- 作者: Denisova V.1
-
隶属关系:
- D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS
- 期: 卷 62, 编号 5 (2013)
- 页面: 29-34
- 栏目: Articles
- URL: https://journals.rcsi.science/jowd/article/view/2592
- DOI: https://doi.org/10.17816/JOWD62529-34
- ID: 2592
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Endometriosis is estrogen- dependent disease. Aromatase P450 is the key enzyme in estrogen biosynthesis. The aim of the study was to compare therapeutic efficiency of gonadotropin-releasing hormone analogue (aGnRH) with ovarian aromatase activity. 64 women with endometriosis were examined after laparoscopic coagulation of endometrioid lesions. The examination included determination of FSH, LH, prolactin, antimüllerian hormone, estradiol, estrone and androstendione by immune-enzyme assay in peripheral blood and determination of ovarian aromatase activity by test with aromatase inhibitor letrozole. Laparoscopic coagulation of endometrioid lesions and following six- month course of aGnRH have lead to decrease of clinical manifestations of the disease and recovery of normal ovulatory menstrual cycle in most (72.5 %) of the patients. Therapeutic efficiency of combined therapy did not depend on basal blood estradiol level and ovarian aromatase activity.
作者简介
Valentina Denisova
D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS
Email: valyik@mail.ru
PhD student
参考
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