Evaluation of aromatase expression in endometrioid heterotopias and endometria in patients with external genital endometriosis
- 作者: Malysheva O.1, Molotkov A.1, Shved N.1, Mikhailova M.1, Yarmolinskaya M.1
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隶属关系:
- The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
- 期: 卷 72, 编号 5 (2023)
- 页面: 39-47
- 栏目: Original Research
- URL: https://journals.rcsi.science/jowd/article/view/255155
- DOI: https://doi.org/10.17816/JOWD568877
- ID: 255155
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详细
BACKGROUND: External genital endometriosis is a multifactorial estrogen-dependent disease. Local estrogen production due to aromatase activity can play an important role in its pathogenesis, so aromatase inhibitors are considered promising drugs for the treatment of the disease. However, the data on their effectiveness are contradictory.
AIM: The aim of this study was to evaluate the expression level of the aromatase-encoding CYP19A1 gene in the eutopic endometrium and endometrioid heterotopies of patients with endometriosis and in the eutopic endometrium of women from the comparison group.
MATERIALS AND METHODS: This study included 79 women. The main group consisted of 55 patients with endometriosis, and 24 patients without endometriosis formed a comparison group. All of the patients underwent an endometrial biopsy during surgery, with excision of endometriotic lesions performed in patients with endometriosis. CYP19A1 gene expression was studied using reverse transcription real-time polymerase chain reaction.
RESULTS: The data obtained confirm a high level of aromatase expression in endometriosis foci. On average, aromatase expression is increased in the eutopic endometrium of patients with endometriosis when compared to the endometrium of women in the comparison group. However, in a significant number of patients with endometriosis, aromatase is expressed in the endometrium at a low level. We did not find an association of increased aromatase expression with any clinical and anamnestic features of the studied group of women, in particular, with infertility, pain syndrome, prevalence of endometriosis, or relapses of the disease.
CONCLUSIONS: Our findings highlight the heterogeneity of endometriosis and may account for the variable effectiveness of hormone-modulating therapy, in particular aromatase inhibitors.
作者简介
Olga Malysheva
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: omal99@mail.ru
ORCID iD: 0000-0002-8626-5071
SPIN 代码: 1740-2691
Cand. Sci. (Biol.)
俄罗斯联邦, Saint PetersburgArsenii Molotkov
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: arseny.molotkov@gmail.com
ORCID iD: 0000-0003-3433-3092
SPIN 代码: 6359-6472
MD, Cand. Sci. (Med.)
俄罗斯联邦, Saint PetersburgNatalia Shved
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: natashved@mail.ru
ORCID iD: 0000-0001-6354-9226
SPIN 代码: 8276-1720
Cand. Sci. (Biol.)
俄罗斯联邦, Saint PetersburgMarina Mikhailova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: mmikh020@gmail.com
ORCID iD: 0009-0001-5828-2245
俄罗斯联邦, Saint Petersburg
Maria Yarmolinskaya
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
编辑信件的主要联系方式.
Email: m.yarmolinskaya@gmail.com
ORCID iD: 0000-0002-6551-4147
SPIN 代码: 3686-3605
MD, Dr. Sci. (Med.), Professor, Professor of the Russian Academy of Sciences
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