电邮这篇文章 Diagnostic value of p16inkα/Ki-67 Dual-stained cytology in HPV-associated cervical diseases
- 作者: Khachaturyan A.1, Orekhova E.2, Tolibova G.3, Tral T.3
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隶属关系:
- I. P. Pavlov State Medical University of St. Petersburg
- EMC clinic
- D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS
- 期: 卷 64, 编号 3 (2015)
- 页面: 47-51
- 栏目: Articles
- URL: https://journals.rcsi.science/jowd/article/view/1251
- DOI: https://doi.org/10.17816/JOWD64347-51
- ID: 1251
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Human papillomavirus (HPV) infection is currently considered the most common of sexually transmitted infections. However, only 8-20 % of cases of infection with human papillomavirus oncogenic risk has the potential to transform to a neoplastic process. Detection of productive forms of HPV infection is the basis of early diagnosis of precancerous lesions. In order to clarify the severity of neoplasia and choose a sufficient way of treatment we investigated the diagnostic value of p16inkα/Ki-67 Dual-stained cytology method for assessing the presence and degree of expression of p16inkα protein and Ki-67, biomarkers of virus-induced proliferation, the sensitivity and positive predictive value of co-expression degree of which can increase the diagnostic value of cervical cytology.
作者简介
Armine Khachaturyan
I. P. Pavlov State Medical University of St. Petersburg
Email: armine2709@rambler.ru
associate professor of the chair of Obstetrics and Gynecology
Ekaterina Orekhova
EMC clinic
Email: orekhovakatherine@gmail.com
оbstetrician-gynecologist
Gulrukhsor Tolibova
D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS
Email: gulyatolibova@mail.ru
PhD. MD. Senior Scientist. Laboratory of Cell Biology, Department of Pathomorphology
Tatyana Tral
D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS
Email: TTG2008@bk.ru
MD. Pathologist. Department of Pathomorphology
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