Role of molecular signaling pathways in the pathogenesis of adenomyosis
- Authors: Shalina M.A.1, Yarmolinskaya M.I.1,2, Netreba E.A.1, Beganova A.K.3
-
Affiliations:
- The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
- North-Western State Medical University named after I.I. Mechnikov
- Saint Petersburg State University
- Issue: Vol 70, No 3 (2021)
- Pages: 121-134
- Section: Reviews
- URL: https://journals.rcsi.science/jowd/article/view/57192
- DOI: https://doi.org/10.17816/JOWD57192
- ID: 57192
Cite item
Abstract
The prevalence of genital endometriosis and adenomyosis, in particular, is tending to increase. The lack of a complete understanding of the pathogenetic mechanisms and multifactorial causes of adenomyosis, the low effectiveness of existing drug therapy, and the importance of preserving reproductive function make it necessary to further study the pathogenesis of the disease, search for new non-invasive highly informative diagnostic methods and develop a new strategy for pathogenically based drug therapy. The review presents current data on the role of signaling pathways in the pathogenesis of the development of adenomyosis based on domestic and foreign literature sources retrieved from the electronic databases PubMed, CyberLeninka, and Google Scholar in the period from 1999 to 2020. Considerable emphasis is placed on the discussion of the research results in recent years. Based on the analysis, the role of transforming growth factor â (TGFβ), vascular endothelial growth factor (VEGF), dual-specificity protein phosphatase (PTEN), Notch receptors, and eukaryotic translation initiation factors (eIFs) in the signaling of adenomyosis is presented. Further advanced study of signaling pathways in the pathogenesis of adenomyosis will allow developing highly specific and highly sensitive markers for non-invasive diagnostics, as well as new directions for drug treatment of the disease.
Full Text
##article.viewOnOriginalSite##About the authors
Maria A. Shalina
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Author for correspondence.
Email: amarus@inbox.ru
ORCID iD: 0000-0002-5921-3217
SPIN-code: 6673-2660
Scopus Author ID: 57200072308
ResearcherId: A-7180-2019
MD, Cand. Sci. (Med.)
Russian Federation, Saint PetersburgMaria I. Yarmolinskaya
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; North-Western State Medical University named after I.I. Mechnikov
Email: m.yarmolinskaya@gmail.com
ORCID iD: 0000-0002-6551-4147
SPIN-code: 3686-3605
Scopus Author ID: 7801562649
ResearcherId: P-2183-2014
MD, Dr. Sci. (Med.), Professor, Professor of the Russian Academy of Sciences
Russian Federation, Saint PetersburgElena A. Netreba
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Email: dr.netlenka@yandex.ru
ORCID iD: 0000-0002-0485-3612
SPIN-code: 9193-3154
Scopus Author ID: 1093545
Russian Federation, Saint Petersburg
Alexandra K. Beganova
Saint Petersburg State University
Email: alexandra.beganova@yandex.ru
ORCID iD: 0000-0002-4705-7990
Russian Federation, Saint Petersburg
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