Email this article Features of the morphological structure of endometrial infiltrates in women with chronic pelvic pain syndrome
- Authors: Efimenko T.O1, Kogan I.Y.1, Tral T.G1, Molotkov A.S1, Tolibova G.K.1
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Affiliations:
- FSBSI «D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology»
- Issue: Vol 65, No 1 (2016)
- Pages: 26-33
- Section: Articles
- URL: https://journals.rcsi.science/jowd/article/view/2928
- DOI: https://doi.org/10.17816/JOWD65126-33
- ID: 2928
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Abstract
Background. There is no clear idea of what factors determine the characteristics of pain in endometriosis. Scientific data on the relationship between morphological and functional features of heterotopic tissue, and the intensity of the pain syndrome is extremely small. Purposes and tasks. To determine the features of the morphological structure of endometrial infiltrates in women with chronic pelvic pain syndrome. Materials and methods. We examined 32 patients with infiltrative endometriosis. Pain intensity was determined in accordance with a 10-point visual analog scale (VAS). Preparation of material for histological study was carried out during the execution of the operating laparoscopy. Histological sections stained with hematoxylin and eosin. The study was conducted with increasing ×100. Histological examination was carried out a descriptive and semi-quantitative assessment of glandular-stromal component biopsy, infiltration of inflammatory cells number, as well as the presence of blood vessels (arterioles, venules). Statistical analysis of the material was carried out using the Microsoft Excel 2013 and Stastistica 10.0 for Windows. Results. During the correlation analysis of the relationship between the intensity of pain and the severity of the vascular component revealed a strong correlation (Rs = 0.71, p < 0.05). With the severity of glandular-stromal component biopsy revealed moderate correlation (Rs = 0.49, p < 0.05). With the severity of the inflammatory infiltration of a number of cells revealed that there is no correlation (Rs = -0.1, p > 0.05). Conclusions. In severe degree of pain severity predominated infiltrates a lot of glands and stroma expressed vascular component, multiple foci of hemorrhage and severe degree of infiltration of inflammatory cells number. When pain syndrome of moderate severity, as in mild, was found mostly poorly and moderately pronounced glandular-stromal component, and infiltration of inflammatory cells number.
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##article.viewOnOriginalSite##About the authors
Tatyana O Efimenko
FSBSI «D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology»
Email: lllu3a@yandex.ru
graduate student
Igor Yu Kogan
FSBSI «D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology»
Email: ikogan@mail.ru
doctor of medical sciences, professor
Tatyana G Tral
FSBSI «D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology»
Email: ttg.tral@yandex.ru
candidate of medical sciences
Arseniy S Molotkov
FSBSI «D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology»
Email: arseny.molotkov@gmail.com
candidate of medical sciences
Gulrukhsor Kh Tolibova
FSBSI «D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology»
Email: gulyatolibova@mail.ru
candidate of medical sciences
References
- Flor H, Turk DC. Chronic pain: An Integrated Biobehavioral Approach. Informa Healthcare Publishing Group. 2011;20(1):117-118. doi: 10.1016/j.cbpra.2012.10.001.
- Vercellini P, Somigliana E, Vigano P, et al. Chronic pelvic pain in women: etiology, pathogenesis and diagnostic approach. Gynecol Endocrinol. 2009;25(3):149-158. doi: 10.1080/09513590802549858.
- Ярмолинская М.И. Генитальный эндометриоз: влияние гормональных, иммунологических и генетических факторов на развитие, особенности течения и выбор терапии: Автореф. дис. … д-ра мед. наук. - СПб., 2009. [Jarmolinskaja MI. Genital endometriosis: effects of hormonal, immunological and genetic factors on the development of the course and the choice of therapy [dissertation]. Saint Petersburg; 2009. (In Russ).]
- Fauconnier A, Fritel X, Chapron C. Endometriosis and pelvic pain: epidemiological evidence of the relationship and implications. Gynecol Obstet Fertil. 2009;37(1):57-69. doi: 10.1016/j.gyobfe.2008.08.016.
- Laufer MR, Goitein L, Bush M, et al. Prevalence of endometriosis in adolescent girls with chronic pelvic pain not responding to conventional therapy. J Pediatr Adolesc Gynecol. 1997;10(4):199-202. doi: 10.1016/s1083-3188(97)70085-8.
- Carter JE. Combined hysteroscopic and laparoscopic findings in patients with chronic pelvic pain. J Am Ass Gynecol Lapar. 1994;2:43-47. doi: 10.1016/s1074-3804(05)80830-8.
- Колосов А.Е. Эндометриоз, эндометриоидные кисты и эндометриодный рак яичников: Автореф. дис. … д-ра мед. наук. - Л., 1985. [Kolosov AE. Endometriosis, endometrial cysts and endometriod ovarian cancer [dissertation]. Leningrad;1985. (In Russ).]
- Адамян Л.В., Кулаков В.И. Эндометриозы. - М.: Медицина, 1998. [Adamjan LV, Kulakov VI. Endometriosis. M.: Medicina; 1998. (In Russ).]
- Баскаков В.П. Клиника и лечение эндометриоза. Л.: Медицина, 1990. [Baskakov VP. Clinic and treatment of endometriosis. Leningrad: Medicina; 1990. (In Russ).]
- Баскаков В.П., Цвелев Ю.В., Кира Е.Ф. Эндометриоидная болезнь. - СПб.: ООО «Издательство Н-Л», 2002. [Baskakov VP, Cvelev JuV, Kira EF. Endometriod disease. Saint Petersburg: OOO “Izdatel’stvo N-L”; 2002. (In Russ).]
- Железнов Б.И., Стрижаков А.Н. Генитальный эндометриоз. - М.: Медицина, 1985. [Zheleznov BI, Strizhakov AN. Genital endometriosis. Moscow: Medicina; 1985. (In Russ).]
- Laganà AS, Salmeri FM, Retto G, et al. Stage-related changes of peritoneal soluble TNFα and TNFR 1 and TNFR 2 in cells recovered from peritoneal fluid of women with endometriosis. J Reprod Immunol. 2012;94(1):94-95. doi: 10.1016/j.jri.2012.03.417.
- Raab S, Plate KH. Different networks, common growth factors: shared growth factors and receptors of the vascular and the nervous system. Acta Neuropathol. 2007;113(6):607-626. doi: 10.1007/s00401-007-0228-3.
- Dabrosin C, Gyorffy S, Margetts P, et al. Therapeutic effect of angiostatin gene transfer in a murine model of endometriosis. Am J Pathol. 2002;161(3):909-918. doi: 10.1016/s0002-9440(10)64251-4.
