Features of the gene polymorphism of estrogen and progesterone receptors in women with uterine leiomyoma

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Uterine Leiomyoma (Leiomyoma) (LM) — benign and most common (incidence 20–45 %) hormone-dependent tumors of female genital organs. Comparative analysis of frequencies of polymorphic variants of genes of estrogen receptor (ERα) and progesterone receptor (PGR) in patients with LM and the population samples was conducted in this work. Also it was investigated their association with clinical manifestation of hyperplastic processes of the female reproductive system. It was founded that the development of LM are not associated with individual polymorphic variants of genes of estrogen receptor and progesterone receptor. This fact does not include their participation in the development of proliferative and hyperplastic processes of the myometrium

作者简介

Natalya Osinovskaya

Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: natosinovskaya@mail.ru
PhD, senior research fellow of the laboratory of prenatal diagnostics of congenial and hereditary diseases

Tatyana Ivaschenko

Ott Research Institute of Obstetrics and Gynecology, RAMS

Dr. Sci, Prof., Leading Researcher of the laboratory of prenatal diagnostics of congenial and hereditary diseases

Lyailya Dzhemlikhanova

St. Petersburg State University

PhD, associate professor, Faculty of Medicine, Department of Obstetrics, Gynecology and Reproductology

Vladislav Baranov

D. O. Ott Institute of Obstetrics and Gynecology

head of lab.for Prenatal Diagnosis, MD, professor

Antonina Tkachenko

St. Petersburg State University

student (6-th cours), Faculty of Medicine, Department of Obstetrics, Gynecology and Reproductology

Iskender Sultanov

Ott Research Institute of Obstetrics and Gynecology, RAMS

assistant of laboratory of prenatal diagnostics of congenial and hereditary diseases

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版权所有 © Osinovskaya N.S., Ivaschenko T.E., Dzhemlikhanova L.K., Baranov V.S., Tkachenko A.N., Sultanov I.Y., 2012

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