Determination of papilloma-virus infection reproductive phase in algorithm of monitoring patients with cervical displasia
- Authors: Selkov S.A.1,2, Vedeneeva G.N.1,2, Baskakova I.A.1,3, Baur S.R.4
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Affiliations:
- Research Institute of Obstetrics and Gynecology named after D.O. Otta RAMS
- 22 city women's consultation
- 22nd city women's consultation
- Virofem Diagnostica GmbH
- Issue: Vol 51, No 4 (2002)
- Pages: 61-63
- Section: Current public health problems
- URL: https://journals.rcsi.science/jowd/article/view/91125
- DOI: https://doi.org/10.17816/JOWD91125
- ID: 91125
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Abstract
HPV 16 and 18 are known to be the main cause of cervical intraepithelial neoplasia (CIN) and cervical cancer. The terms of HPV persistence in the host and, coordinately, the risk of cervical neoplasia development and progression are determined in much extent by virus activity. The purpose of this investigation was the detection of HPV DNA presence in cervical epithelium as well as confirmation of its activity by means of immunocytochemistry and reverse transcriptase polymerase chain reaction. The level of HPV inf ection by oncogenic and nononcogenic types in 181 women with different cervical pathology was 55,8%. The active stage of HPV infection was confirmed in 27,5% of HPV-inf ected women mainly with low grades of CIN. The proof of reproductive general HPV infection was more informative with RT PCR just as for HPV 16 and 18 immunocytochemistry and RT PCR completed each anothe.
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##article.viewOnOriginalSite##About the authors
S. A. Selkov
Research Institute of Obstetrics and Gynecology named after D.O. Otta RAMS; 22 city women's consultation
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Saint Petersburg; Saint Petersburg
G. N. Vedeneeva
Research Institute of Obstetrics and Gynecology named after D.O. Otta RAMS; 22 city women's consultation
Email: info@eco-vector.com
Russian Federation, Saint Petersburg; Saint Petersburg
I. A. Baskakova
Research Institute of Obstetrics and Gynecology named after D.O. Otta RAMS; 22nd city women's consultation
Email: info@eco-vector.com
Russian Federation, Saint Petersburg; Saint Petersburg
S. R. Baur
Virofem Diagnostica GmbH
Email: info@eco-vector.com
Germany, Wiesbaden, Hessen