Email this article Revealing histamine-sensible activity of Wood umbilical cord serum in experiments with ring segments of arteries and umbilical cord vein and with myometrium strips of pregnant women
- Authors: Tsyrkin V.I.1,2, Sazanova M.L.1,2, Dvorianskiy S.A.1,2, Khlybova S.V.1,2
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Affiliations:
- State Medical Academy
- State Pedagogical University
- Issue: Vol 51, No 4 (2002)
- Pages: 55-60
- Section: Current public health problems
- URL: https://journals.rcsi.science/jowd/article/view/91123
- DOI: https://doi.org/10.17816/JOWD91123
- ID: 91123
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Abstract
In experiments with 60 segments of arteries and 46 segments of the umbilical cord vein of 24 newborns and 35 strips of myometrium of 12 pregnant women, the effect of 100-fold dilutions of cord blood serum (SPK-1: 100) on the contractile effects of histamine (0.01, 0.1 and 1 ϻg l ml). SPK-1: - 100 increased the vasoconstrictor and uterostimulating effects of histamine.
H1-histaminosensitizing activity of SPK-1: 100 and the efficiency of activation of H1-histamine receptors of myocytes of the arteries and umbilical cord veins are increased in the presence of obstetric complications. A conclusion was made about the content of endogenous sensitizer H1-histamine receptors (ESGR) in the fetal blood, the level of which increases in the presence of obstetric complications, as well as the possible role of histamine and ESGR in the regulation of fetoplacental blood circulation in conditions of normal and pathological conditions.
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##article.viewOnOriginalSite##About the authors
V. I. Tsyrkin
State Medical Academy; State Pedagogical University
Author for correspondence.
Email: info@eco-vector.com
Department of Normal Physiology and Department of Obstetrics and Gynecology, Department of Anatomy, Physiology and Valeology
Russian Federation, Kirov; KirovM. L. Sazanova
State Medical Academy; State Pedagogical University
Email: info@eco-vector.com
Department of Normal Physiology and Department of Obstetrics and Gynecology, Department of Anatomy, Physiology and Valeology
Russian Federation, Kirov; KirovS. A. Dvorianskiy
State Medical Academy; State Pedagogical University
Email: info@eco-vector.com
Department of Normal Physiology and Department of Obstetrics and Gynecology, Department of Anatomy, Physiology and Valeology
Russian Federation, Kirov; KirovS. V. Khlybova
State Medical Academy; State Pedagogical University
Email: info@eco-vector.com
Department of Normal Physiology and Department of Obstetrics and Gynecology, Department of Anatomy, Physiology and Valeology
Russian Federation, Kirov; KirovReferences
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