Particularities of morphogenesis of human fetus brain

The review is devoted to the basic events of human fetal CNS development. The cellular processes of two broad phases of cerebral morphogenesis — cytogenesis/histogenesis and differentiation/growth — are described. In this review we also concern the main regressive events in the CNS development such as programmed cell death (apoptosis), axonal pruning and synaptic elimination. Different environmental factors may effect human brain development even from its early stages causing brain injury that can result in major or minor cerebral malformations. So, the knowledge of the main questions of fetal brain morphogenesis can helpto prevent some abnomalities of CNS in the future child development.