The role of antiphospholipid antibodies on the pathogenesis of habitual pregnancy loss

O. N. Arzhanova; Аржанова О. Н.; T. N. Shliakhtenko; Шляхтенко Т. Н.; S. А. Selkov; Сельков С. А.; T. А. Pluzhnikova; Плужникова Т. А.; О. V. Tishkevitch; Тышкевич О. В.; А. V. Fedorenko; Федоренко А. В.; E. A. Shapovalova; Шаповалова Е. А.

doi:10.17816/JOWD90372

The role of antiphospholipid antibodies on the pathogenesis of habitual pregnancy loss

Authors: Arzhanova O.N.¹, Shliakhtenko T.N.¹, Selkov S.А.¹, Pluzhnikova T.А.¹, Tishkevitch О.V.¹, Fedorenko А.V.¹, Shapovalova E.A.¹
Affiliations:
1. Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Issue: Vol 51, No 2 (2002)
Pages: 18-22
Section: Scientific activity
URL: https://journals.rcsi.science/jowd/article/view/90372
DOI: https://doi.org/10.17816/JOWD90372
ID: 90372

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Abstract

Clinical and anamnesis analysis as well as analysis of the course and outcome of the present pregnancy was performed on 595 patients with complicated obstetrical and gynecological history (COGH) — habitual pregnancy loss, infertility, genital chronic processes. Control groupconsisted of 5O healthy women. Immunofluorescent analysis was used to reved antiphospholipid antibodies on blood plasma. Antiphospholipid antibodies were found in 42% of COGH women. No antiphospholipid antibodies were seen in the control group. In all patients of the studied groupthe course of pregnancy was accompanied with signs of threatened abortion, gestosis. 29% (p< O, O1) patients had preterm labor and spontaneous abortion occurred in 18% (p< O, O1) of cases. Perinatal mortality was 9, 8%±4, 16.

Keywords

the role of antiphospholipid antibodies, AFA, pathogenesis of miscarriage

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