Effects of two monophasic oral contraceptives containing 150 mcg of desogestrel in combination with 20 or 30 mcg of ethinylestradiol on adolescent girls with oligomenorrhea and ovarian hyperandrogenism

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Abstract

Adolescent girls in the early years after their first menstruation are characterized by frequent irregular menstrual cycles and absence of ovulation, often associated with clinical signs of hyperandrogenism, including hirsutism and acne. Often in these adolescent girls, both the ovarian structure and endocrine characteristics do not allow to distinguish the disease from polycystic ovarian syndrome (PCOS) observed in adults.

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2. Fig. 1. Mean plasma FSH and LH concentrations (± standard deviation) before treatment and during the third and sixth treatments with two oral contraceptives containing 20 µg EE, 150 µg desogestrel (shaded rectangles) or 30 µg EE, 150 µg desogestrel (unshaded rectangles) in adolescents with ovarian hyperandrogenism: compared with baseline values: * p < 0.05, ** p < 0.01.

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3. Fig. 2. Mean plasma concentrations of free and total T, hGH, and A.

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4. Fig. 3. Mean plasma concentrations of DHEA-C.

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5. Fig. 4. Average ovarian volume and number of ovarian cysts.

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6. Fig. 5. Average percentage reduction in hirsutism index.

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