Danoval and omnadren effect on the patients with dysfunctional uterine bleedings during the premenopause

Initial level of gonadothropic, steroid hormones in the blood, receptors of estradiol and progesteron of the endometrium in the patients with dysfunctional uterine bleedings during the premenopause, and their dunamics during and after hormone therapy were studied.

Danoval and oxy prog esterone-capronat in combination with omnadren had different effect on the parameters of the hormonal homeostasis and receptor apparatus of the endometrium. Antigonadоthropic effect of danoval results in FSG level reduction, estradiol and progesterone decrease in the blood and that of steroid receptors in the endometrium, that did not take place with other therapies. The effectiveness of the treatment with danoval was 88,24%, and it was 62,50% when oxy prog esterone-capronat with omnadren therapy was used.

It is concluded that danoval prescription to the patients with dysfunctional uterine bleedings during the menopause is more expedient for the wide spectrum of antigonadothropic effect.