To a problem of the markers of vessels wall at EPH-gestosis
- Authors: Ailamasian E.K.1, Zainulina M.S.1, Petrishev N.N.1
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Affiliations:
- Pavlov State Medical University
- Issue: Vol 47, No 1 (1998)
- Pages: 19-23
- Section: Original Research
- URL: https://journals.rcsi.science/jowd/article/view/86949
- DOI: https://doi.org/10.17816/JOWD86949
- ID: 86949
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Abstract
Content in blood of markers of damage of a vessel wall (factor Willebrand, tissue of a catalyst plasminogen, cells circulating in blood endothelium), and also intravessel an aggregate platelet and uterine - placental bloodcurrent at 205 patients, among which woman with physiological current of pregnancy and with EPH-gestosis of a various degree of weight is investigated. The patients with nephropathy and preeclampsy were divided into groups depending on a method of treatment.
The 46 pregnant with EPH-gestosis of a various degree of weight was carried by clofelin in a daily doze 0,00015-0,0003 g during 7-10 days, 42 women therapy (the course doze 25,5-27 g of dry substance) is spent magnesium, 59 pregnant received clofelin and magnesium therapy in the above-stated dozes. The group of comparison formed 38 patients.
It was shown the important value of a research of markers of damage endothelium for diagnostics, definition of a degree of weight and control for efficiency of therapy pregnant with EPH-gestosis. Clofelin and magnesium, used for treatment of pregnant with EPH-gestosis as is independent, and in a combination, have endotheliumprotection operation, as reduce in authentic decrease of a content in blood of a marker of vessel's disorders of circulating cells endothelium, and also reduce intravessel an aggregate of platelets and improve uterine-placental bloodcurrent.
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##article.viewOnOriginalSite##About the authors
E. K. Ailamasian
Pavlov State Medical University
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, St. Petersburg
M. S. Zainulina
Pavlov State Medical University
Email: info@eco-vector.com
Russian Federation, St. Petersburg
N. N. Petrishev
Pavlov State Medical University
Email: info@eco-vector.com
Russian Federation, St. Petersburg